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PAK1 Antibodies
AND PAK1 ELISA kits, PAK1 Proteins
Many biological assays use antibodies to detect PAK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PAK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PAK1 antibodies...
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PAK1 Infographic by Boster Bio
All PAK1 Products
Product
Figures
Specificity
Applications
Price
Anti-PAK1 Monoclonal Antibody
15 Q&As
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00454
100 μl
Cat # M00454
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1436
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1436
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2102
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2102
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2103
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2103
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2574
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2574
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00454T212-1
100ul
Cat # A00454T212-1
100ul
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00454S144
100ul
Cat # A00454S144
100ul
Human, Monkey, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00454S199
100ul
Cat # A00454S199
100ul
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00454S204
100ul
Cat # A00454S204
100ul
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00454T423
100ul
Cat # A00454T423
100ul
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00454-2
100 μg/vial
Cat # A00454-2
100 μg/vial
PAK1 Overview
Facts about Serine/threonine-protein kinase PAK 1.
Serine/threonine-protein kinase PAK 1 (PAK1)
Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an significant role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells from apoptosis.
Activated by discussion with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway.
Gene Information
| Human | |
|---|---|
| Gene Name: | PAK1 |
| Uniprot: | Q13153 |
| Entrez: | 5058 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
alpha-PAK; EC 2.7.11; EC 2.7.11.1; MGC130000; MGC130001; p21 protein (Cdc42/Rac)-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21-activated kinase 1; p65-PAK; PAK1; PAK-1; PAKalpha; serine/threonine-protein kinase PAK 1; STE20 homolog, yeast
Molecular Weight
Mass (kDA):
60.647 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.5-q14.1 |
| Sequence: | 11; NC_000011.10 (77322017..77514957, complement) |
Tissue Specificity
Overexpressed in gastric cancer cells and tissues (at protein level) (PubMed:25766321).
Subcellular Localizations
Cytoplasm. Cell junction, focal adhesion. Cell membrane. Cell projection, ruffle membrane. Cell projection, invadopodium. Nucleus, nucleoplasm. Chromosome. Colocalizes with RUFY3, F-actin and other core migration components in invadopodia at the cell periphery (PubMed:25766321). Recruited to the cell membrane by interaction with CDC42 and RAC1. Recruited to focal adhesions upon activation. Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Upon DNA damage, translocates to the nucleoplasm when phosphorylated at Thr-212 where is co-recruited with
Diseases
- Malignant Neoplasms
- Neoplasms
- Tissue Adhesions
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Carcinoma
- Cell Invasion
- Cell Transformation, Neoplastic
- Neoplasm Metastasis
- Tumor Angiogenesis
- Malignant Paraganglionic Neoplasm
- Neoplasm Invasiveness
- Neurofibromatoses
Interacting Proteins
- ARHGEF7
- CDC42
- Cdc42
- CDK11B
- CRIPAK
- GIT1
- LIMK1
- NCK2
- PCBP1
- RAC1
Pathways
- Cell Migration
- Cell Motility
- Localization
- Cell Proliferation
- Cell Growth
- Cell Cycle
- Angiogenesis
- Pathogenesis
- Cell Adhesion
- Mitosis
- Wound Healing
- Secretion
- Chemotaxis
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Myristoylation
- Ribosylation
- Methylation
- Amidation
Research Areas
- Apoptosis
- Breast Cancer
- Cancer
- Neuroscience
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAK1
bosterbio.com/bosterbio-gene-info-cards/PAK1
References
PMID: 8805275 by Brown J.L., et al. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway.
PMID: 9395435 by Sells M.A., et al. Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells.