PAG1 Antibodies

AND PAG1 ELISA kits, PAG1 Proteins

Many biological assays use antibodies to detect PAG1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PAG1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PAG1 antibodies...

We validate the specificity of these antibodies to PAG1 by testing them on tissues known to express PAG1 positively and negatively. Browse below to find the PAG1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PAG1 Infographic by Boster Bio

All PAG1 Products

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Product

Figures

Specificity

Applications

Price

Anti-PAG1 Purified Monoclonal Antibody

Cow, Human, Mouse, Rat

IP, IHC-P, WB

$330
Cat # M03711
0.1 mg

Anti-PAG Rabbit Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, IP, IHC, WB

$370
Cat # M03711-1
100 μl/vial

PAG (PAG1) (NM_018440) Human Over-expression Lysate

Human

$960
Cat # LS055824
100 µg

PAG1 Overview

Facts about Phosphoprotein associated with glycosphingolipid-enriched microdomains 1.

PAG1 3D structure. Source: alphafold

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1)

Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which leads to LCK inhibition.

Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.

Gene Information

Human
Gene Name:	PAG1
Uniprot:	Q9NWQ8
Entrez:	55824

Family

Belongs to:

No superfamily

Alternative Names

CBP; CBPMGC138364; Csk-binding protein; PAG1; PAGFLJ37858; phosphoprotein associated with glycosphingolipid microdomains 1; phosphoprotein associated with glycosphingolipid-enriched microdomains 1; Transmembrane adapter protein PAG; Transmembrane phosphoprotein Cbp

Molecular Weight

Mass (kDA):
46.981 kDA

Genomic Context


Human

Location:	8q21.13
Sequence:	8; NC_000008.11 (80967810..81112068, complement)

Tissue Specificity

Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level).

Subcellular Localizations

Cell membrane; Single-pass type III membrane protein. Present in lipid rafts.

Diseases

Malignant Neoplasms
Neoplasms
Cell Transformation, Neoplastic
Lymphoma
Malignant Paraganglionic Neoplasm
Virus Diseases
Metaplastic Cell Transformation
Inflammation
Tumor Progression
Cell Invasion
Alzheimer's Disease
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse
Leukemia

Posttransfusion Purpura
Prostatic Neoplasms
Malignant Neoplasm Of Lung
Allergy
Infective Disorder
Malignant Neoplasm Of Prostate
Nerve Degeneration

Interacting Proteins

CSK
FYN
LYN
RACK1

Pathways

Cell Activation
Localization
T Cell Activation
Cell Proliferation
Cell Cycle
Cell Death
Rna Interference
Secretion
Mast Cell Activation
Histone Acetylation
Mating
Pathogenesis
Hyperphosphorylation

Platelet Aggregation
Induction Of Apoptosis
Cytokine Production
Cell Adhesion
Transposition
Cell Migration
Colony Morphology

PTMs

Phosphorylation
Dephosphorylation
Acetylation
Palmitoylation
Ubiquitination

Reduction
Cleavage
Glycosylation
Oxidation
Methylation

Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAG1

References

PMID: 10790433 by Brdicka T., et al. Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.

PMID: 11684085 by Brdickova N., et al. Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton.