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PA2G4 Antibodies
AND PA2G4 ELISA kits, PA2G4 Proteins
Many biological assays use antibodies to detect PA2G4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PA2G4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PA2G4 antibodies...
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PA2G4 Infographic by Boster Bio
All PA2G4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$523
Cat # M02791
100 µl
Cat # M02791
100 µl
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02791-1
100 μl/vial
Cat # M02791-1
100 μl/vial
PA2G4 Overview
Facts about Proliferation-associated protein 2G4.
Proliferation-associated protein 2G4 (PA2G4)
May play a part in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation.
Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, likely by recruiting histone acetylase (HAT) activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | PA2G4 |
| Uniprot: | Q9UQ80 |
| Entrez: | 5036 |
Family
| Belongs to: |
|---|
| peptidase M24 family |
Alternative Names
Cell cycle protein p38-2G4 homolog; EBP1; ErbB-3 binding protein 1; ErbB3-binding protein 1; ErbB3-binding protein Ebp1; HG4-1; p38-2G4; PA2G4; proliferation-associated 2G4, 38kD; proliferation-associated 2G4, 38kDa; proliferation-associated protein 2G4
Molecular Weight
Mass (kDA):
43.787 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.2 |
| Sequence: | 12; NC_000012.12 (56104559..56113910) |
Tissue Specificity
Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver.
Subcellular Localizations
[Isoform 1]: Cytoplasm. Nucleus, nucleolus. Translocates to the nucleus upon treatment with HRG. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization.; [Isoform 2]: Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Malignant Neoplasm Of Prostate
- Mammary Neoplasms
- Prostatic Neoplasms
- Retinoblastoma
- Carcinoma
- Cell Transformation, Neoplastic
- Neoplasm Invasiveness
- Colorectal Neoplasms
Interacting Proteins
- NCL
- RB1
- SIN3A
Pathways
- Cell Cycle
- Cell Growth
- Cell Proliferation
- Localization
- Translation
- Immune Response
- Reverse Transcription
- Mitosis
- Regeneration
- Ribosome Biogenesis
- Dna Replication
- S Phase
- Cell Adhesion
PTMs
- Phosphorylation
- Sumoylation
Research Areas
- Cell Cycle and Replication
- Core ESC-Like Genes
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PA2G4
bosterbio.com/bosterbio-gene-info-cards/PA2G4
References
PMID: 9345902 by Lamartine J., et al. Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4.
PMID: 10682683 by Yoo J.Y., et al. Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin.