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P4HB Antibodies
AND P4HB ELISA kits, P4HB Proteins
Many biological assays use antibodies to detect P4HB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with P4HB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop P4HB antibodies...
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P4HB Infographic by Boster Bio
All P4HB Products
Product
Figures
Specificity
Applications
Price
Bovine, Chicken, Dog, Guinea pig, Hamster, Human, Monkey, Mouse, Rabbit, Rat, Sheep, Xenopus, Porcine
Flow Cytometry
$935
Cat # E02335
200μg/vial
Cat # E02335
200μg/vial
Human
ELISA
$499
Cat # EK1890
96 wells/kit, with removable strips.
Cat # EK1890
96 wells/kit, with removable strips.
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02335-1
100 μg/vial
Cat # A02335-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M02335-2
100 μl/vial
Cat # M02335-2
100 μl/vial
P4HB Overview
Facts about Protein disulfide-isomerase.
Protein disulfide-isomerase (P4HB)
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to serve as a reductase which cleaves disulfide bonds of proteins attached to the cell.
May therefore cause structural modifications of exofacial proteins. Within the cell, seems to form/rearrange disulfide bonds of nascent proteins.
Gene Information
| Human | |
|---|---|
| Gene Name: | P4HB |
| Uniprot: | P07237 |
| Entrez: | 5034 |
Family
| Belongs to: |
|---|
| protein disulfide isomerase family |
Alternative Names
Cellular thyroid hormone-binding protein; collagen prolyl 4-hydroxylase beta; DSI; ERBA2L; GIT; glutathione-insulin transhydrogenase; P4HB; P4Hbeta; p55; PDI; PDIA1; PDIA1procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), betapolypeptide (protein disulfide isomerase-associated 1); PDIEC 5.3.4.1; PHDB; PO4DB; PO4HB; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), betapolypeptide; PROHB; PROHBprocollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), betapolypeptide (protein disulfide isomerase; thyroid hormone binding protein p5
Molecular Weight
Mass (kDA):
57.116 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q25.3 |
| Sequence: | 17; NC_000017.11 (81843159..81860535, complement) |
Subcellular Localizations
Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Cell membrane; Peripheral membrane protein. Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources (Probable). Localizes near CD4-enriched regions on lymphoid cell surfaces (PubMed:11181151). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:10636893). Colocalizes with MTTP in the endoplasmic reticulum (PubMed:23475612).
Diseases
- Polyendocrinopathies, Autoimmune
- Malignant Neoplasms
- Neoplasms
- Neurofibromatosis 1
- Inflammation
- Hypoxia
- Neoplasm Metastasis
- Melanoma
- Fibrosis
- Tumor Angiogenesis
- Tissue Adhesions
- Radiation Injury
Interacting Proteins
- ERO1A
- HM13
- PRDX4
- TAP1
Pathways
- Cell Proliferation
- Cell Death
- Tissue Development
- Localization
- Cell Cycle
- Response To Hypoxia
- Methylation
- Angiogenesis
- Glycolysis
- Cell Migration
- Meiosis Ii
- Fertilization
- Spermatogenesis
PTMs
- Phosphorylation
- Hydroxylation
- Glycosylation
Research Areas
- Cellular Markers
- ER Markers
- Fibroblast Cell Markers
- Hypoxia
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/P4HB
bosterbio.com/bosterbio-gene-info-cards/P4HB
References
PMID: 3034602 by Pihlajaniemi T., et al. Molecular cloning of the beta-subunit of human prolyl 4-hydroxylase. This subunit and protein disulphide isomerase are products of the same gene.
PMID: 3611107 by Cheng S.-Y., et al. The nucleotide sequence of a human cellular thyroid hormone binding protein present in endoplasmic reticulum.
1 Publications of Boster P4HB Antibodies & ELISA Kits
- PubMed ID: 10.3748/wjg.v24.i22.2381, Prognostic value of hypoxia-inducible factor-1 alpha and prolyl 4-hydroxylase be...
*More publications can be found for each product on its corresponding product page