P2X purinoceptor 5 Antibodies

P2X purinoceptor 5 (P2RX5)

Receptor for ATP that acts as a ligand-gated ion channel. .

Gene Information

Human
Gene Name:	P2RX5
Uniprot:	Q93086
Entrez:	5026

Family

Belongs to:
P2X receptor family

Alternative Names

ATP receptor subunit; ATP receptor; ionotropic ATP receptor P2X5; LRH-1; MGC47755; P2RX5; P2X purinoceptor 5; P2X5; P2X5lymphoid-restricted histocompatibility antigen-1; P2X5R; purinergic receptor P2X ligand gated ion channel 5; purinergic receptor P2X, ligand-gated ion channel, 5; Purinergic receptor

Molecular Weight

Mass (kDA):
47.205 kDA

Genomic Context

Human
Location:	17p13.2
Sequence:	17; NC_000017.11 (3673227..3696155, complement)

Tissue Specificity

Expressed at high levels in brain and immune system.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

• Malignant Neoplasms
• Neoplasms
• Graft-vs-host Disease
• Varicosity
• Myeloid Leukemia, Chronic
• Leukemia
• Disease Of Adrenal Medulla
• Myeloid Leukemia
• Malignant Paraganglionic Neoplasm
• Leukemia, Myelocytic, Acute
• Nervousness
• Radiation Injury
• Detrusor Instability

• Melanoma
• Malignant Neoplasm Of Breast
• Inflammatory Bowel Diseases
• Malignant Neoplasm Of Brain
• Intestinal Diseases
• Carcinoma
• Ulcer

Pathways

• Localization
• Innervation
• Regeneration
• Synaptic Transmission
• Keratinocyte Differentiation
• Reverse Transcription
• Cell Death
• Keratinocyte Proliferation
• Response To Atp
• Bioluminescence
• Cell Adhesion
• Myoblast Proliferation
• Cell Activation

• Cell Proliferation
• Muscle Cell Differentiation
• T Cell Activation
• Interferon-gamma Production
• Sensitization
• Cell Differentiation
• Wound Healing

PTMs

• Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/P2RX5

Best Uses Of The P2RX5 Marker

Boster Bio: Anti FSH Receptor/FSHR Antibody Pikoband is a unique marker to aid scientists in the identification FSH. This product is used by scientists to submit results in applications, species, and for special samples. Scientists can also receive product credits for submitting findings. This product is used all over the globe by scientists to determine FSH levels for various species and tissue types.

Boster Bio: Anti FSH/FSHR Antibody Picoband

FSH is a receptor that interacts directly with the FSHR protein. This antibody can detect any changes in this protein in human serum. Boster Bio has tested the FSHR marker in mice to determine its FSH binding activity. Mice were first treated with FSH for 48 hours and then left untreated for 24 hours. After that, the mice were fixed in 44% paraffin wax and embedded in it. Sections were then deparaffinized and blocked in BSA-PBS 5 to determine their FSHR expression levels.

Boster Bio Anti FSH/FSCR/Antibody has been tested for use in Immunofluorescence, Western blotting (WB), and other applications. It is non-hazardous and can be stored at -20degC for up to a year. Boster bio Anti-FSH Receptor/FSHR Antibody are available in a 1.0mg/ml size. The Boster Bio Anti FSHR Antibody Picoband cost approximately $165, and is shipped directly.

FSHR, a transmembrane proteins, is essential to normal ovarian maturation and follicle development. The FSHR is an essential component of ovarian development. It stimulates Sertoli-cell growth and supports spermatogenesis. FSH binds with cells via a FSHR receptor (FSH Receptor/FSHR). This protein is part of a subfamily of receptors known as G protein-coupled receptors (GPCRs) and shares the role of high affinity hormone binding.

Indivumed was a German integrated company that specializes in oncology. They tested several antibodies against hFSHR, and validated them with paraffin-embedded and other epitope retrieval techniques. Three antibodies were found to be specific for binding to hFSHR in its native form. The receptor was detected at physiological concentrations by FSHR323 in both histochemical and IHC settings.

The FSHR also known as vascular FSHR is found within tumor-associated vascular Epithelial Cells. Although its function is still unclear, it is known as a transmembrane-protein. Although the exact function of the FSHR remains elusive, it is believed to have beneficial effects in the treatment of cancer. Picoband, an Anti-FSHR Antibody Picoband is a great choice for clinical trials.

This FSHR antibody provides high-quality results for cancer studies. It is suitable for the target validation of the hFSHR in IHC-PET. However, it was not confirmed by previous studies. Further validation confirmed that FSHR expression is restricted to peripheral blood vessels. These findings support anti-hFSHR antibodies being used in cancer research.