P2X purinoceptor 2 Antibodies

P2X purinoceptor 2 (P2RX2)

Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, understanding of flavor and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, internal ear gap junctions, and K(+) recycling.

Mediates synaptic transmission between neurons and from neurons to smooth muscle. .

Gene Information

Human
Gene Name:	P2RX2
Uniprot:	Q9UBL9
Entrez:	22953

Family

Belongs to:
P2X receptor family

Alternative Names

ATP receptor; MGC129601; P2RX2; P2X purinoceptor 2; P2X2; P2X2P2X Receptor, subunit 2; purinergic receptor P2X, ligand-gated ion channel, 2; Purinergic receptor

Molecular Weight

Mass (kDA):
51.754 kDA

Genomic Context

Human
Location:	12q24.33
Sequence:	12; NC_000012.12 (132618776..132623736)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Localizes to the apical membranes of hair cells in the organ of Corti.

Diseases

• Pain
• Nervousness
• Inflammation
• Hyperalgesia
• Disease Of Adrenal Medulla
• Pituitary Diseases
• Pheochromocytoma
• Neuralgia
• Hyperalgesias, Mechanical
• Varicosity
• Hypoxia
• Pathological Dilatation

• Anoxia
• Thermal Hyperalgesia
• Astrocytoma
• Malignant Neoplasms
• Nerve Damage
• Retinoblastoma

Pathways

• Localization
• Response To Atp
• Innervation
• Synaptic Transmission
• Transport
• Sensitization
• Regeneration
• Cell Death
• Reflex
• Exocytosis
• Membrane Hyperpolarization
• Neurogenesis
• Hypersensitivity

• Translation
• Cell Cycle
• Secretion
• Cell Adhesion
• Myoblast Proliferation
• Axon Regeneration
• Biosynthetic Process

PTMs

• Phosphorylation
• Glycosylation
• Carboxylation

• Reduction
• Dephosphorylation
• Ubiquitination

Research Areas

• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/P2RX2

Boster Bio: Best Uses Of The Anti-P2RX2 Marker

Boster Bio: Best Uses Of The Anti-P2RX2 Marker has become a highly popular option for scientists to test samples. This unique tool is useful for scientists conducting research on species, applications, and special samples. Scientists worldwide can benefit from its features and benefits. Boster scientists can also submit their results for product credits and special samples. All these advantages are applicable to all scientists.

Anti-P2X2 P2RX2 Marker

The best use for the P2RX2 marker is to monitor an individual's immune response to the influenza vaccine. This marker was first discovered by researchers in immunology. These researchers are now using this marker in their work. In their book, they discuss how it can be used to monitor an individual's immune response to influenza vaccine. The results of the study have been published in several scientific journals.

Typical applications

The P2RX2 marker is a protein that is expressed in many cancers. However, not all cancers express P2RX2 or overexpress it. For these cancers to express P2RX2, they must show certain characteristics that make them suitable for use as a biomarker. Here are some examples of the typical applications of this gene marker. If you have a blood-brain barrier-associated cancer, the P2RX2 gene expression in your tumor is higher than the normal brain tissue.

This protein is an overexpressed gene. It is expressed in cancer cells at higher levels than its wild-type counterpart. For this reason, the P2RX2 marker has been used to monitor the progression of various cancers and diagnose them early. When the P2RX2 marker is overexpressed in a tumor cell, it has a shorter half-life than that of a non-cancerous cell.

Molecular analysis has also revealed that P2RX4 is expressed in sensory neurons, which are responsible for detecting cancer. Using deep RNA sequencing, researchers confirmed the presence of P2RX4 mRNA in distinct populations of nociceptive neurons and DRG neurons. Nonetheless, the role of P2RX4 in sensory neurons and its function in inflammatory pain remains elusive.

The P2RX2 marker can be used to monitor the progression of tumors in the presence of an inhibitor RNA. These compounds can reduce the activity of P2RX2 by targeting the protein's binding partner or increasing its size. It is possible to chemically synthesize and/or transcribe P2RX2 using an in vitro method. The resulting inhibitor RNA molecule can inhibit the P2RX2 enzyme and thus block the signaling process.

Besides studying the role of P2RX2 in neuronal functions, P2RX2 also plays an important role in the acoustic process. In fact, it plays an important role in the spatial location of ribbon synapses, which is crucial for the transfer of acoustic information. Because it is upregulated in small nociceptive neurons during long-lasting inflammation, P2RX2 is a good marker for long-term research in neurological diseases.

Safety

The P2RX2 gene is a member of the purinoceptor family. It functions as a ligand-gated ion channel and mediates the transmission of synaptic signals between neurons and smooth muscle cells. This gene has six transcript variants, encoding six distinct isoforms. It has been linked to progressive hearing loss. Its function in brain development is currently unknown.