OTU domain-containing protein 7B (OTUD7B)

Negative regulator of this non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of this NF-kappa-B pathway, thus acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B.

Deubiquitinates ZAP70, and thus modulates T cell receptor (TCR) signaling that contributes to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, such as production of IFNG and IL2 (By similarity).