Osteocrin Antibodies

AND Ostn ELISA kits, Osteocrin Proteins

Many biological assays use antibodies to detect Osteocrin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Osteocrin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Osteocrin antibodies...

We validate the specificity of these antibodies to Osteocrin by testing them on tissues known to express Ostn positively and negatively. Browse below to find the Ostn antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Ostn Infographic by Boster Bio

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Osteocrin (OSTN) (NM_198184) Human Over-expression Lysate

Human

$628
Cat # LS344901
100 µg

Ostn Overview

Facts about Osteocrin.

Osteocrin (Ostn)

Hormone that serves as a ligand for natriuretic peptide receptor NPR3/NPR-C and promotes bone growth and physical endurance . Acts as a regulator of osteoblast differentiation and bone growth by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, resulting in increase cGMP production (PubMed:14523025, PubMed:17951249).

Required to improve physical endurance: triggered following physical exercise in muscle and promotes cGMP production, probably by interacting with NPR3/NPR-C (PubMed:26668395). May act as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle (PubMed:15044443).

Gene Information

Mouse
Gene Name:	Ostn
Uniprot:	P61364
Entrez:	239790

Family

Belongs to:

Osteocrin family

Alternative Names

Musclin; Osteocrin; OSTN

Molecular Weight

Mass (kDA):
14.438 kDA

Genomic Context


Mouse

Location:	16\|16 B2
Sequence:	16;

Tissue Specificity

Expressed in skeletal muscle and to a much lesser extent in bone, brown adipose tissue, spleen and testis (PubMed:14523025, PubMed:15044443, PubMed:26668395). Not expressed in neurons (PubMed:27830782).

Diseases

Crest Syndrome
Embryonal Carcinoma
Kidney Failure, Chronic
Cleft Palate
Kidney Failure, Acute
Oestrogen Deficiency
Acquired Kyphosis
Kidney Failure
Hyperinsulinism
Carcinoma

Hypertrophy
Obesity
Leukemia
Diaphragmatic Hernia

Pathways

Cell Differentiation
Cell Cycle
Osteoblast Differentiation
Bone Remodeling
Regulation Of Gene Expression
Oxidative Phosphorylation
Rna Interference
Localization

Chondrocyte Proliferation
Secretion

PTMs

Cleavage

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Ostn

References

PMID: 14523025 by Thomas G., et al. Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype.

PMID: 15044443 by Nishizawa H., et al. Musclin, a novel skeletal muscle-derived secretory factor.