OSGEP Antibodies

AND OSGEP ELISA kits, OSGEP Proteins

Many biological assays use antibodies to detect OSGEP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with OSGEP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop OSGEP antibodies...

We validate the specificity of these antibodies to OSGEP by testing them on tissues known to express OSGEP positively and negatively. Browse below to find the OSGEP antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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OSGEP Infographic by Boster Bio

All OSGEP Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-OSGEP Antibody

Human, Mouse, Rat

IF, WB

$405
Cat # A13000
100ul

Human OSGEP Recombinant Protein

SDS-PAGE, Denatured

$250
Cat # PROTQ9NPF4
Starting from 20ug

Anti-OSGEP Mouse Monoclonal Antibody [Clone ID: OTI8B3]

Human, Mouse, Rat

IF, IHC, WB

$523
Cat # M13000
100 µl

Anti-OSGEP Mouse Monoclonal Antibody [Clone ID: OTI9E3]

Dog, Human, Mouse, Rat

Flow Cytometry, IHC, WB

$523
Cat # M13000-1
100 µl

OSGEP (NM_017807) Human Over-expression Lysate

Human

$628
Cat # LS055644
100 µg

OSGEP Overview

Facts about Probable tRNA N6-adenosine threonylcarbamoyltransferase.

OSGEP 3D structure. Source: alphafold

Probable tRNA N6-adenosine threonylcarbamoyltransferase (OSGEP)

Part of the EKC/KEOPS complex that's necessary for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons starting with adenine. The complex is probably involved in the transfer of this threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.

OSGEP probably plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. .

Gene Information

Human
Gene Name:	OSGEP
Uniprot:	Q9NPF4
Entrez:	55644

Family

Belongs to:

KAE1 / TsaD family

Alternative Names

EC 3.4.24.57; GCPL1FLJ20411; hOSGEP; KAE1; OSGEP1; O-sialoglycoprotein endopeptidase; probable O-sialoglycoprotein endopeptidase; PRSMG1; t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP

Molecular Weight

Mass (kDA):
36.427 kDA

Genomic Context


Human

Location:	14q11.2
Sequence:	14; NC_000014.9 (20446401..20454812, complement)

Tissue Specificity

Widely expressed at low level. Expressed in heart, placenta, liver, kidney, lung, brain, skeletal muscle and pancreas.

Subcellular Localizations

Cytoplasm. Nucleus.

Diseases

Neoplasms
Cell Transformation, Neoplastic
Malignant Neoplasms
Melanoma
Leukemia
Epidemic Keratoconjunctivitis
Neurodegenerative Disorders

Acute Promyelocytic Leukemia

Interacting Proteins

LAGE3
TP53RK

Pathways

Dna Repair
Mitochondrial Genome Maintenance
Cell Death
Oncogenesis

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OSGEP

References

PMID: 12039036 by Seki Y., et al. Sequencing analysis of a putative human O-sialoglycoprotein endopeptidase gene (OSGEP) and analysis of a bidirectional promoter between the OSGEP and APEX genes.

PMID: 22912744 by Costessi A., et al. The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME.