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OSBPL3 Antibodies
AND OSBPL3 ELISA kits, OSBPL3 Proteins
Many biological assays use antibodies to detect OSBPL3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with OSBPL3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop OSBPL3 antibodies...
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OSBPL3 Overview
Facts about Oxysterol-binding protein-related protein 3.
Oxysterol-binding protein-related protein 3 (OSBPL3)
Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204).
The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324).
Gene Information
| Human | |
|---|---|
| Gene Name: | OSBPL3 |
| Uniprot: | Q9H4L5 |
| Entrez: | 26031 |
Family
| Belongs to: |
|---|
| OSBP family |
Alternative Names
DKFZp667P1518; KIAA0704ORP3ORP-3OSBP3; MGC21526; OSBP-related protein 3; oxysterol binding protein-like 3; oxysterol-binding protein 3; oxysterol-binding protein-related protein 3
Molecular Weight
Mass (kDA):
101.224 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p15.3 |
| Sequence: | 7; NC_000007.14 (24796537..24980218, complement) |
Tissue Specificity
Expressed in a subset of small lymphocytes (at protein level). Expressed at high concentration in kidney, lymph node and thymus. Expressed at moderate concentration in stomach, jejunum, ileum, appendix, spleen, leukocytes, trachea, lung and thyroid gland. Expressed at low concentration in whole brain, esophagus, duodenum, ileocecum, colon, skeletal muscle, bone marrow, placenta and mammary gland (PubMed:14593528). Isoform 1a, isoform 1b, isoform 1c and isoform 1d are highly expressed in brain, bone marrow, colon, kidney, lung, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart and liver. Isoform 2a, isoform 2b, isoform 2c and isoform 2d are expressed in brain, bone marrow, kidney, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart, liver and lung (PubMed:12590732).
Subcellular Localizations
Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell projection, filopodium tip. Nucleus membrane; Peripheral membrane protein. Co-localizes with OSBPL6 at contact sites between the plasma membrane and the endoplasmic reticulum.
Diseases
- Malignant Neoplasms
- Obesity
- Liver Carcinoma
- Leukemia
- Tissue Adhesions
- Lymphoid Leukemia
- Liver Neoplasms, Experimental
Pathways
- Cell Adhesion
- Cell Proliferation
- Mrna Splicing
- Gene Silencing
- Glycolysis
- Secretion
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OSBPL3
bosterbio.com/bosterbio-gene-info-cards/OSBPL3
References
PMID: 11568019 by Gregorio-King C.C., et al. ORP-3, a human oxysterol-binding protein gene differentially expressed in hematopoietic cells.
PMID: 11735225 by Jaworski C.J., et al. A family of 12 human genes containing oxysterol-binding domains.