Protein OS-9 Antibodies

Protein OS-9 (OS9)

Lectin which operates in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins in addition to improperly folded glycoproteins, keep them at the ER, and transfer them to the ubiquitination machinery and promote their degradation.

Potential targets include TRPV4. .

Gene Information

Human
Gene Name:	OS9
Uniprot:	Q13438
Entrez:	10956

Family

Belongs to:
OS-9 family

Alternative Names

Amplified in osteosarcoma 9; endoplasmic reticulum lectin 2; ERLEC2; erlectin 2; OS-9; osteosarcoma amplified 9, endoplasmic reticulum associated protein; osteosarcoma amplified 9, endoplasmic reticulum lectin; protein OS-9

Molecular Weight

Mass (kDA):
75.562 kDA

Genomic Context

Human
Location:	12q13.3-q14.1
Sequence:	12; NC_000012.12 (57693955..57721557)

Tissue Specificity

Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines. Isoform 2 is the major isoform detected in all cell types examined.

Subcellular Localizations

Endoplasmic reticulum lumen.

Diseases

• Neoplasms
• Osteosarcoma
• Malignant Neoplasms
• Dislocations
• Hypoxia
• Sarcoma
• Physiological Stress
• Von Hippel-lindau Syndrome
• Neoplasms, Experimental
• Neoplasm Metastasis
• Melanoma
• Tumor Progression

• Bone Neoplasms
• Malignant Neoplasm Of Lung
• Carcinoma
• Endoplasmic Reticulum Stress
• Insulin Resistance
• Cytomegalovirus Infections
• Myeloid Leukemia

Interacting Proteins

• EGLN1
• EGLN3
• HIF1A

Pathways

• Secretory Pathway
• Transport
• Localization
• Protein Folding
• Rna Interference
• Oxygen Homeostasis
• Cell Proliferation
• Response To Hypoxia
• Glycosylation
• Response To Endoplasmic Reticulum Stress
• Conjugation
• Flight

• Translation
• Cell Growth
• Interphase
• Lipid Storage
• Viral Replication
• Secretion

PTMs

• Glycosylation
• Ubiquitination

• Phosphorylation
• Biotinylation

• Hydroxylation

Research Areas

• Cancer
• Chromatin Research
• Hypoxia
• Immunology

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OS9

Boster Bio Anti-OS9 Antibody Picoband - The Best Uses Of The OS9 Marker In Osteosarcomas

Boster Bio Anti OS9 Antibody Picoband may be of interest to scientists. This article will give you a brief history of the product and explain how it works. It will also discuss the best applications for this biomarker to osteosarcomas. It will also provide optimization tips and pointers for researchers worldwide. This article will help guide you in making the most of your tool.

Boster Bio Anti-OS9 Antibody Picoband

Boster Bio Anti-OS9 Antibody Antibody (one of their many products) is one of the company's proprietary products. This immunoassay kit allows you to detect biomarkers in neurosciences, developmental biology, and inflammation. It has a high sensitivity of up to picograms and the technical support team at Sanbio distributor BeNeLux supports it. Boster Bio Anti OS9 Antibody Picoband was validated through the use of 250 tissues. This results shows a high affinity against the antigen.

The product comes in vials containing 4 mg Trehalose per vial. The antibody can be stored at -20°C for up to one year. Each vial contains 0.9% NaCl. It is then reconstituted with blocking protein. For more information on this product, contact Sanbio. You can also submit your results by species or application. The product credits are applicable to researchers worldwide.

The Chinese name for this product is Bo Si Te Sheng Wu Ji Shu. This means "the circle" in Chinese. The ring is also known under the Boster Bio Anti-OS9 Antibody Picoband. It can be found in many labs, including biotech research and medical research. The company also offers a comprehensive range of diagnostic tests for various diseases, including cancer. Because it is a natural immune therapy, there are no clinical trials.

The anti-OS9 antibody was used for immunocytochemical analysis in human HL-60 whole cell extracts. After antigen retrieval by IHC enzyme reagent RA0022 and 10% of goat serum, anti-OS9 antibody was incubated 30 minutes with DyLight!AE488 conjugated anti-rabbit IgG. After incubating for one hours at 37°C, the membrane could be visualized using appropriate filter sets. Finally, it was washed with TBS 0.1%.

Application in osteosarcomas

Proteomic research is increasingly being used to understand the biology and pathogenesis of tumors. These data can be applied to the clinical setting for biomarker identification and can aid the development of novel therapeutic strategies. Osteosarcomas comprise the most common malignant bones tumors. Global protein expression research can provide information regarding osteosarcoma tumour biology. These studies can also help to identify promising biomarkers as well as potential therapeutic targets.

An increased risk of osteosarcoma is linked to genetic factors. People with mutations in RB1 and p53 genes have a higher chance of developing osteosarcoma. Rare genetic disorders, such as osteosarcoma, also pose a greater risk. Nonetheless, there are genetic risk factors that have yet to be identified. More research is needed. Screening is also necessary.

High-grade surface osteosarcoma (HSOS) comprises less than one percent of all OS. It is characterized by a rounded hypochromatic nucleus, little nuclear polymorphism, and production of osteoid. Despite these differences hGSOS is just as dangerous as traditional OS. The disease can also affect the axial skeleton and the pelvis.

Conventional treatment for osteosarcomas is chemotherapy and surgery. In low-grade osteosarcoma, the tumor can be removed by surgical excision alone. If the final pathology confirms that there is no cancer, chemotherapy can be avoided. The goal of surgery to remove the entire tumor is to achieve this goal. If there isn't any cancer spread, the surgical options available to you include limb rescue and amputation.

Research results show that serum levels of certain proteins associated with osteosarcoma may be associated with prognosis and malignant grade. This could help to distinguish osteosarcomas and benign bone tumors, and allow for the development of new therapeutics. PRDX protein should be the primary target for diagnostic and prognostic Biomarkers. Targeted therapy is possible with some of the targets.

Recent research has identified proteins associated to metastasis, chemoresistance, and metastasis. The researchers isolated five pairs from surgical specimens to create cell lines. 56 protein spots were detected that were differentially expressing. They identified sixteen of these proteins using a nanoliquid chromatography/electrospray ionization tandem mass spectrometry. The researchers also confirmed the differential expression of ezrin and alphacrystallin B in osteosarcoma.

History of Steven Boster

Steven Boster began his career in 1993 when he invented his first product. He has been developing hundreds of primary antibody products and various products for immunohistochemistry. Steven Boster, China's largest anti-biotic catalog company, had reached its peak in the late 90s. His company now uses proprietary trade secrets for high-sensitivity ELISA kits. He was also a passionate sports fan, and attended many races and games against other teams.

Steve Boster was born June 6, 2022. He was born in Joliet (IL) to Evelyn Meier, and James Boster. He was a veteran of the Army and a member Concordia Hall in Staunton. His family includes two Daughters, Natosha Peck and Crystal Boster, 6 Grandchildren, 4 Brothers (Jack Boster, Sandra Blanton, Tammy and David), and many nieces and nephews.

Optimization tips

Optimizing ELISA tests for the OS9 marker requires many decisions at various steps. Sample preparation, blocking buffer, antibodies are all important decisions. Boster Bio can answer common questions like how to choose the appropriate antibody concentration or buffer. Boster Bio optimization tips can help ensure that your ELISA tests are optimized. If you are unsure of what steps to take or how to prepare your samples, the following tips will help.