ORC6 Antibodies

AND ORC6 ELISA kits, ORC6 Proteins

Many biological assays use antibodies to detect ORC6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ORC6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ORC6 antibodies...

We validate the specificity of these antibodies to ORC6 by testing them on tissues known to express ORC6 positively and negatively. Browse below to find the ORC6 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ORC6 Infographic by Boster Bio

All ORC6 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-ORC6 Antibody

Human, Mouse, Rat

IF, IHC, WB

$405
Cat # A05558
100ul

ORC6L (ORC6) (NM_014321) Human Recombinant Protein

$813
Cat # PROTQ9Y5N6
20 µg

ORC6L (ORC6) (NM_014321) Human Over-expression Lysate

Human

$628
Cat # LS023594
100 µg

ORC6 Overview

Facts about Origin recognition complex subunit 6.

ORC6 3D structure. Source: alphafold

Origin recognition complex subunit 6 (ORC6)

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent.

The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex essential to initiate DNA replication.

Gene Information

Human
Gene Name:	ORC6
Uniprot:	Q9Y5N6
Entrez:	23594

Family

Belongs to:

ORC6 family

Alternative Names

ORC6Lorigin recognition complex, subunit 6 homolog-like (yeast); origin recognition complex subunit 6; origin recognition complex, subunit 6 like (yeast); origin recognition complex, subunit 6

Molecular Weight

Mass (kDA):
28.107 kDA

Genomic Context


Human

Location:	16q11.2
Sequence:	16; NC_000016.10 (46689656..46698394)

Subcellular Localizations

Nucleus.

Diseases

Dwarfism
Ear, Patella, Short Stature Syndrome
Microcephaly
Congenital Small Ears
Malignant Neoplasms
Chromosomal Duplication
Hypoplasia
Micrognathism
Growth Disorders
Colonic Neoplasms
Malignant Tumor Of Colon
Seckel Syndrome

Neoplasms
Pulmonary Emphysema
Colorectal Cancer
Atrophy Of Breast
Salivary Gland Diseases
Malignant Paraganglionic Neoplasm

Interacting Proteins

HMGA1
LHX4
ORC3
ORC4
SPAG5

Pathways

Dna Replication
Cell Cycle
Mitosis
Cytokinesis
S Phase
Cell Division
Cell Proliferation
Chromosome Segregation
G1 Phase
Localization
M Phase
Dna Replication Initiation
Cell Death

Rna Interference
Protein Phosphorylation
Transport
Gene Silencing
Fertilization
Proteolysis
Ribosome Assembly

PTMs

Phosphorylation

Cleavage

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ORC6

References

PMID: 17716973 by Siddiqui K., et al. ATP-dependent assembly of the human origin recognition complex.

PMID: 22427655 by Chan K.M., et al. Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing.