Olfactomedin-4 Antibodies

AND OLFM4 ELISA kits, Olfactomedin-4 Proteins

Many biological assays use antibodies to detect Olfactomedin-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Olfactomedin-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Olfactomedin-4 antibodies...

We validate the specificity of these antibodies to Olfactomedin-4 by testing them on tissues known to express OLFM4 positively and negatively. Browse below to find the OLFM4 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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OLFM4 Infographic by Boster Bio

All OLFM4 Products

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Specificity

Applications

Price

Anti-OLFM4 Monoclonal Antibody

Human, Mouse, Rat

IP, WB

$370
Cat # M04094
100 μl

Anti-OLFM4 Antibody Picoband®

13 Q&As

Human, Mouse, Rat

ELISA, IHC, WB

$370
Cat # A04094-1
100 μg/vial

OLFM4 Overview

Facts about Olfactomedin-4.

OLFM4 3D structure. Source: alphafold

Olfactomedin-4 (OLFM4)

May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis.

May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.

Gene Information

Human
Gene Name:	OLFM4
Uniprot:	Q6UX06
Entrez:	10562

Family

Belongs to:

No superfamily

Alternative Names

Antiapoptotic protein GW112; bA209J19.1; GC1; G-CSF-stimulated clone 1 protein; GW112; GW112hOLfD; hGC-1; KIAA4294; olfactomedin 4; Olfactomedin-4; OlfD; OLFM4; OLM4; UNQ362

Molecular Weight

Mass (kDA):
57.28 kDA

Genomic Context


Human

Location:	13q14.3
Sequence:	13; NC_000013.11 (53028813..53052057)

Tissue Specificity

Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues.

Subcellular Localizations

Secreted, extracellular space. Mitochondrion. Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901 and PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901).

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Stomach
Stomach Neoplasms
Neoplasm Metastasis
Carcinogenesis
Adenocarcinoma
Colorectal Cancer
Colorectal Neoplasms
Cell Transformation, Neoplastic
Carcinoma
Pancreatic Neoplasm

Cell Invasion
Tissue Adhesions
Malignant Neoplasm Of Gastrointestinal Tract
Prostatic Neoplasms
Tumor Progression
Malignant Neoplasm Of Pancreas

Interacting Proteins

CCDC155
LDLRAD1
NOD1
NOD2
SYNE4

Pathways

Cell Cycle
Cell Proliferation
Cell Growth
Cell Adhesion
Translation
Cell Death
Cell Differentiation
S Phase
Angiogenesis
Protein Biotinylation
Glycosylation
Immune Response
Localization

Demethylation
Sensitization
Tissue Remodeling
Response To Hydrogen Peroxide
Rna Interference
Secretion
Autophagy

PTMs

Phosphorylation
Demethylation

Biotinylation
Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OLFM4

References

PMID: 11867215 by Zhang J., et al. Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development.

PMID: 15059901 by Zhang X., et al. GW112, a novel antiapoptotic protein that promotes tumor growth.