OFD1 Antibodies

AND OFD1 ELISA kits, OFD1 Proteins

Many biological assays use antibodies to detect OFD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with OFD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop OFD1 antibodies...

We validate the specificity of these antibodies to OFD1 by testing them on tissues known to express OFD1 positively and negatively. Browse below to find the OFD1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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OFD1 Infographic by Boster Bio

All OFD1 Products

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Product

Figures

Specificity

Applications

Price

Anti-OFD1 Antibody Picoband®

Human, Mouse, Rat

Flow Cytometry, IF, ICC, WB

$370
Cat # A02955-1
100 μg/vial

OFD1 (NM_003611) Human Over-expression Lysate

Human

$960
Cat # LS008481
100 µg

OFD1 Overview

Facts about Oral-facial-digital syndrome 1 protein.

OFD1 3D structure. Source: alphafold

Oral-facial-digital syndrome 1 protein (OFD1)

Component of the centrioles controlling mother and daughter centrioles length. Recruits into the centriole IFT88 and centriole distal appendage-specific proteins such as CEP164.

Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells necessary to transduce signals important for development and tissue homeostasis.

Gene Information

Human
Gene Name:	OFD1
Uniprot:	O75665
Entrez:	8481

Family

Belongs to:

OFD1 family

Alternative Names

JBTS10; MGC117039; oral-facial-digital syndrome 1; SGBS2

Molecular Weight

Mass (kDA):
116.671 kDA

Genomic Context


Human

Location:	Xp22.2
Sequence:	X; NC_000023.11 (13734713..13773978)

Tissue Specificity

Widely expressed. Expressed in 9 and 14 weeks old embryos in metanephric mesenchyme, oral mucosa, lung, heart, nasal and cranial cartilage, and brain. Expressed in metanephros, brain, tongue, and limb.

Subcellular Localizations

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Localizes to centriole distal ends and to centriolar satellites (PubMed:20230748, PubMed:24121310). Localization to centrioles and pericentriolar satellites may be mediated by KIAA0753/OFIP (PubMed:26643951).

Diseases

Orofaciodigital Syndromes
Orofaciodigital Syndrome I
Kidney Diseases
Polycystic Kidney Diseases
Cystic Kidney Diseases
Familial Aplasia Of The Vermis
Hypoxia
Congenital Abnormality
Polydactyly
Dysplasia
Cleft Palate
Genetic Diseases, X-linked

Retinitis Pigmentosa
Nephronophthisis
Nervousness
Kidney Failure, Chronic
Developmental Disabilities
Simpson-golabi-behmel Syndrome, Type 1
Cystic Disease -retired-

Interacting Proteins

C2CD3
MAP1LC3B
NME7
PCM1
PLK1

RUVBL1

Pathways

Localization
Pathogenesis
Cell Migration
Translation
Bone Development
Mitosis
Transport
Proteolysis
Immune Response
Regulation Of Gene Expression
Limb Development
Dosage Compensation
Chromosome Segregation

Reflex
Sterol Homeostasis
Cilium Assembly
Response To Oxygen Levels
Microtubule Depolymerization
Axon Guidance
Cell Cycle

PTMs

Phosphorylation

Hydroxylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OFD1

References

PMID: 9722947 by de Conciliis L., et al. Characterization of Cxorf5 (71-7A), a novel human cDNA mapping to Xp22 and encoding a protein containing coiled-coil alpha-helical domains.

PMID: 12595504 by Romio L., et al. OFD1, the gene mutated in oral-facial-digital syndrome type 1, is expressed in the metanephros and in human embryonic renal mesenchymal cells.