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- Table of Contents
Facts about P protein.
One of the elements of the mammalian pigmentary system. Appears to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis.
Human | |
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Gene Name: | OCA2 |
Uniprot: | Q04671 |
Entrez: | 4948 |
Belongs to: |
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CitM (TC 2.A.11) transporter family |
BEY; BEY1; BEY2; D15S12BOCA; EYCL; EYCL2; eye color 2 (central brown); eye color 3 (brown); hair color 3 (brown); HCL3; Melanocyte-specific transporter protein; oculocutaneous albinism II (pink-eye dilution (murine) homolog); oculocutaneous albinism II (pink-eye dilution homolog, mouse); oculocutaneous albinism II; P protein; PED; PEYCL3; Pink-eyed dilution protein homolog; SHEP1; total brown iris pigmentation
Mass (kDA):
92.85 kDA
Human | |
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Location: | 15q12-q13.1 |
Sequence: | 15; NC_000015.10 (27719008..28099342, complement) |
Melanosome membrane; Multi-pass membrane protein.
PMID: 8421497 by Rinchik E.M., et al. A gene for the mouse pink-eyed dilution locus and for human type II oculocutaneous albinism.
PMID: 7601462 by Lee S.-T., et al. Organization and sequence of the human P gene and identification of a new family of transport proteins.