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NXF1 Antibodies
AND NXF1 ELISA kits, NXF1 Proteins
Many biological assays use antibodies to detect NXF1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NXF1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NXF1 antibodies...
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NXF1 Overview
Facts about Nuclear RNA export factor 1.
Nuclear RNA export factor 1 (NXF1)
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus into the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA along with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949).
ALYREF/THOC4-bound mRNA is supposed to be moved into the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 eases m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244).
Gene Information
| Human | |
|---|---|
| Gene Name: | NXF1 |
| Uniprot: | Q9UBU9 |
| Entrez: | 10482 |
Family
| Belongs to: |
|---|
| NXF family |
Alternative Names
DKFZp667O0311; Mex67; mRNA export factor TAP; nuclear RNA export factor 1; TAPMEX67; tip associating protein; Tip-associated protein; Tip-associating protein
Molecular Weight
Mass (kDA):
70.182 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q12.3 |
| Sequence: | 11; NC_000011.10 (62792125..62805443, complement) |
Tissue Specificity
Expressed ubiquitously.
Subcellular Localizations
Nucleus. Nucleus, nucleoplasm. Nucleus speckle. Nucleus, nuclear pore complex. Nucleus envelope. Cytoplasm. Cytoplasm, Stress granule. Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. The association with the TREX complex seems to occur in regions surrounding nuclear speckles known as perispeckles (PubMed:23826332). Nucleus; nuclear rim (PubMed:25662211).
Diseases
- Influenza
- Hiv Infections
- Immunologic Deficiency Syndromes
- Virus Diseases
- Branchio-oto-renal Syndrome
- Ataxia
- Vesicular Stomatitis
- Fragile X Syndrome
- Neurodegenerative Disorders
- Stomatitis
- Leukemia
Interacting Proteins
- ALYREF
- CHTOP
- DDX3X
- DHX9
- DVL3
- GFAP
- KRT40
- LDOC1
- NUP62
- NXT1
Pathways
- Nuclear Export
- Transport
- Localization
- Translation
- Nuclear Transport
- Nucleocytoplasmic Transport
- Rna Interference
- Viral Replication
- Nuclear Import
- Rna Processing
- Rna Transport
- Mrna Processing
- Mrna Transport
PTMs
- Phosphorylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NXF1
bosterbio.com/bosterbio-gene-info-cards/NXF1
References
PMID: 10202158 by Braun I.C., et al. TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus.
PMID: 10323864 by Kang Y., et al. The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences.