NKIRAS1 Antibodies

AND NKIRAS1 ELISA kits, NKIRAS1 Proteins

Many biological assays use antibodies to detect NKIRAS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NKIRAS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NKIRAS1 antibodies...

We validate the specificity of these antibodies to NKIRAS1 by testing them on tissues known to express NKIRAS1 positively and negatively. Browse below to find the NKIRAS1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NKIRAS1 Infographic by Boster Bio

All NKIRAS1 Products

Product

Figures

Specificity

Applications

Price

Anti-KappaB ras NKIRAS1 Antibody

Human, Mouse, Rat

ELISA, IHC-P, WB

$449
Cat # A11990
0.1 mg

Anti-KappaB ras1 NKIRAS1 Antibody

Human, Mouse

ELISA, ICC, WB

$449
Cat # A11990-1
0.1 mg

NKIRAS1 (NM_020345) Human Recombinant Protein

$1249
Cat # PROTQ9NYS0
20 µg

Anti-NKIRAS1 Mouse Monoclonal Antibody [Clone ID: OTI6C11]

Human, Mouse, Rat

IF, IHC, WB

$523
Cat # M11990
100 µl

NKIRAS1 (NM_020345) Human Over-expression Lysate

Human

$628
Cat # LS028512
100 µg

NKIRAS1 Overview

Facts about NF-kappa-B inhibitor-interacting Ras-like protein 1.

NKIRAS1 3D structure. Source: alphafold

NF-kappa-B inhibitor-interacting Ras-like protein 1 (NKIRAS1)

Atypical Ras-like protein that serves as a potent regulator of NF-kappa-B action by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by many signs, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit.

It is unclear whether it functions as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.

Gene Information

Human
Gene Name:	NKIRAS1
Uniprot:	Q9NYS0
Entrez:	28512

Family

Belongs to:

small GTPase superfamily

Alternative Names

I-kappa-B-interacting Ras-like protein 1; kappa B-ras 1; Kappa B-Ras protein 1; KappaB-Ras1; KBRAS1kappaB-Ras1; NF-kappa-B inhibitor-interacting Ras-like protein 1; NFKB inhibitor interacting Ras-like 1; NFKB inhibitor interacting Ras-like protein 1

Molecular Weight

Mass (kDA):
21.643 kDA

Genomic Context


Human

Location:	3p24.2
Sequence:	3; NC_000003.12 (23889949..23946562, complement)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Cytoplasm.

Diseases

Malignant Neoplasms
Neoplasms
Non-small Cell Lung Carcinoma
Malignant Neoplasm Of Lung
Carcinoma
Adenocarcinoma
Neoplasm Metastasis
Malignant Squamous Cell Neoplasm
Lung Neoplasms
Malignant Neoplasm Of Kidney
Tumor Progression
Von Hippel-lindau Syndrome
Malignant Paraganglionic Neoplasm

Kidney Neoplasm
Sarcoma
Carcinogenesis
Renal Cell Carcinoma
Malignant Neoplasm Of Ovary
Epithelial Ovarian Cancer
Ovarian Neoplasm

Pathways

Methylation
Cell Growth

PTMs

Methylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NKIRAS1

References

PMID: 10657303 by Fenwick C., et al. A subclass of Ras proteins that regulate the degradation of IkappaB.

PMID: 12672800 by Chen Y., et al. KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta.NF-kappaB complexes.