Nischarin Antibodies

AND NISCH ELISA kits, Nischarin Proteins

Many biological assays use antibodies to detect Nischarin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nischarin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nischarin antibodies...

We validate the specificity of these antibodies to Nischarin by testing them on tissues known to express NISCH positively and negatively. Browse below to find the NISCH antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NISCH Infographic by Boster Bio

All NISCH Products

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Price

NISCH (NM_007184) Human Recombinant Protein

$813
Cat # PROTQ9Y2I1
20 µg

NISCH (NM_007184) Human Over-expression Lysate

Human

$628
Cat # LS011188
100 µg

NISCH Overview

Facts about Nischarin.

NISCH 3D structure. Source: alphafold

Nischarin (NISCH)

Acts either as the operational imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of this I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration.

Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity).

Gene Information

Human
Gene Name:	NISCH
Uniprot:	Q9Y2I1
Entrez:	11188

Family

Belongs to:

No superfamily

Alternative Names

hIRAS; I-1 receptor candidate protein; I-1FLJ14425; I1R candidate protein; I1R; Imidazoline receptor 1; imidazoline receptor antisera selected; Imidazoline receptor antisera-selected protein; imidazoline receptor candidate; Imidazoline-1 receptor candidate protein; Imidazoline-1 receptor; IR1; IRASFLJ40413; KIAA0975FLJ90519; nischarin

Molecular Weight

Mass (kDA):
166.629 kDA

Genomic Context


Human

Location:	3p21.1
Sequence:	3; NC_000003.12 (52455603..52493068)

Tissue Specificity

Isoform 1, isoform 3 and isoform 4 are expressed in brain. Isoform 1 is expressed in endocrine tissues.

Subcellular Localizations

Cell membrane. Cytoplasm. Early endosome. Recycling endosome. Enriched in the early/sorting and recycling endosomes. Colocalized in early/sorting endosomes with EEA1 and SNX2 and in recycling endosomes with transferrin receptor. Detected in the perinuclear region partially associated with punctate structures (By similarity). Colocalizes with PAK1 in cytoplasm, vesicular structures in the perinuclear area and membrane ruffles (By similarity). Colocalizes with RAC1 in the cytoplasm and vesicles structures (By similarity). Colocalized with MAPK1 and MAPK3 in RVLM neurons (By similarity).