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Endonuclease 8-like 3 Antibodies
AND NEIL3 ELISA kits, Endonuclease 8-like 3 Proteins
Many biological assays use antibodies to detect Endonuclease 8-like 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Endonuclease 8-like 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Endonuclease 8-like 3 antibodies...
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NEIL3 Overview
Facts about Endonuclease 8-like 3.
Endonuclease 8-like 3 (NEIL3)
DNA glycosylase which favors single-stranded DNA (ssDNA), or partially ssDNA structures like bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5- OHMH, Tg and 8-oxoA lesions in ssDNA.
No action on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | NEIL3 |
| Uniprot: | Q8TAT5 |
| Entrez: | 55247 |
Family
| Belongs to: |
|---|
| FPG family |
Alternative Names
DNA glycosylase FPG2; DNA glycosylase hFPG2; DNA glycosylase/AP lyase Neil3; EC 3.2.2.-; EC 4.2.99.18; endonuclease 8-like 3; Endonuclease VIII-like 3; FGP2; FLJ10858; FPG2; hFPG2; hNEI3; nei endonuclease VIII-like 3 (E. coli); NEI3; Nei-like protein 3
Molecular Weight
Mass (kDA):
67.769 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q34.3 |
| Sequence: | 4; NC_000004.12 (177309871..177362936) |
Tissue Specificity
Expressed in keratinocytes and embryonic fibroblasts (at protein level). Also detected in thymus, testis and fetal lung primary fibroblasts.
Subcellular Localizations
Nucleus.
Diseases
- Adenoma
- Malignant Neoplasms
- Neoplasms
- Cholangiocarcinoma
- Hypoxia
- Carcinoma
- Carcinogenesis
- Brain Hypoxia
- Immunologic Deficiency Syndromes
- Memory Impairment
- Colorectal Cancer
- Colorectal Adenoma
Pathways
- Dna Repair
- Neurogenesis
- Cell Proliferation
- Brain Development
- Cell Death
- Base-excision Repair
- Stem Cell Differentiation
- Cell Development
- Aging
- Senescence
- Dna Replication
PTMs
- Cleavage
Research Areas
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NEIL3
bosterbio.com/bosterbio-gene-info-cards/NEIL3
References
PMID: 12200441 by Takao M., et al. A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue.
PMID: 12433996 by Morland I., et al. Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA.