Endonuclease 8-like 3 Antibodies

AND NEIL3 ELISA kits, Endonuclease 8-like 3 Proteins

Many biological assays use antibodies to detect Endonuclease 8-like 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Endonuclease 8-like 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Endonuclease 8-like 3 antibodies...

We validate the specificity of these antibodies to Endonuclease 8-like 3 by testing them on tissues known to express NEIL3 positively and negatively. Browse below to find the NEIL3 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NEIL3 Infographic by Boster Bio

All NEIL3 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-EPHA10 NEIL3 Antibody

Human

$360
Cat # A05497
100 µl

Anti-NEIL3/Nei3 Antibody

3 Q&As

Human, Mouse

$399
Cat # A05497-1
100μl

Anti-Endonuclease 8-like 3 NEIL3 Antibody

Human, Mouse, Rat

$405
Cat # A05497-2
100ul

Anti-Endonuclease 8-like 3 NEIL3 Antibody

Human, Mouse

ELISA, IHC, WB

$380
Cat # A05497-3
100ul

NEI3 (NEIL3) (NM_018248) Human Over-expression Lysate

Human

$628
Cat # LS055247
100 µg

Anti-NEIL3 Antibody Picoband®

Human, Mouse, Rat

ELISA, IHC, WB

$370
Cat # A05497-4
100 µg/vial

NEIL3 Overview

Facts about Endonuclease 8-like 3.

NEIL3 3D structure. Source: alphafold

Endonuclease 8-like 3 (NEIL3)

DNA glycosylase which favors single-stranded DNA (ssDNA), or partially ssDNA structures like bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5- OHMH, Tg and 8-oxoA lesions in ssDNA.

No action on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity.

Gene Information

Human
Gene Name:	NEIL3
Uniprot:	Q8TAT5
Entrez:	55247

Family

Belongs to:

FPG family

Alternative Names

DNA glycosylase FPG2; DNA glycosylase hFPG2; DNA glycosylase/AP lyase Neil3; EC 3.2.2.-; EC 4.2.99.18; endonuclease 8-like 3; Endonuclease VIII-like 3; FGP2; FLJ10858; FPG2; hFPG2; hNEI3; nei endonuclease VIII-like 3 (E. coli); NEI3; Nei-like protein 3

Molecular Weight

Mass (kDA):
67.769 kDA

Genomic Context


Human

Location:	4q34.3
Sequence:	4; NC_000004.12 (177309871..177362936)

Tissue Specificity

Expressed in keratinocytes and embryonic fibroblasts (at protein level). Also detected in thymus, testis and fetal lung primary fibroblasts.

Subcellular Localizations

Nucleus.

Diseases

Adenoma
Malignant Neoplasms
Neoplasms
Cholangiocarcinoma
Hypoxia
Carcinoma
Carcinogenesis
Brain Hypoxia
Immunologic Deficiency Syndromes
Memory Impairment
Colorectal Cancer
Colorectal Adenoma

Anoxia
Brain Injuries
Asphyxia
Malignant Neoplasm Of Prostate
Ischemia
Liver Carcinoma
Induced Hypothermia (finding)

Pathways

Dna Repair
Neurogenesis
Cell Proliferation
Brain Development
Cell Death
Base-excision Repair
Stem Cell Differentiation
Cell Development
Aging
Senescence
Dna Replication

Cell Cycle
Isotype Switching
Cell Differentiation
S Phase
Rna Interference

PTMs

Cleavage

Oxidation

Research Areas

DNA Repair

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NEIL3

References

PMID: 12200441 by Takao M., et al. A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue.

PMID: 12433996 by Morland I., et al. Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA.