NUDT3 Antibodies

AND NUDT3 ELISA kits, NUDT3 Proteins

Many biological assays use antibodies to detect NUDT3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NUDT3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NUDT3 antibodies...

We validate the specificity of these antibodies to NUDT3 by testing them on tissues known to express NUDT3 positively and negatively. Browse below to find the NUDT3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NUDT3 Infographic by Boster Bio

All NUDT3 Products

Product

Figures

Specificity

Applications

Price

Human NUDT3 Recombinant Protein

SDS-PAGE

$250
Cat # PROTO95989
Starting from 10ug

NUDT3 Overview

Facts about Diphosphoinositol polyphosphate phosphohydrolase 1.

NUDT3 3D structure. Source: alphafold

Diphosphoinositol polyphosphate phosphohydrolase 1 (NUDT3)

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) isn't a substrate.

Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates.

Gene Information

Human
Gene Name:	NUDT3
Uniprot:	O95989
Entrez:	11165

Family

Belongs to:

Nudix hydrolase family

Alternative Names

Diadenosine 5'-5'''-P1; diphosphoinositol polyphosphate phosphohydrolase 1; DIPP-1; DIPPDIPP1; EC 3.6.1.-; EC 3.6.1.52; Nucleoside diphosphate-linked moiety X motif 3; nudix (nucleoside diphosphate linked moiety X)-type motif 3; Nudix motif 3; P6-hexaphosphate hydrolase 1

Molecular Weight

Mass (kDA):
19.471 kDA

Genomic Context


Human

Location:	6p21.31
Sequence:	6; NC_000006.12 (34279679..34392669, complement)

Tissue Specificity

Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also expressed in placenta, lung and kidney.

Subcellular Localizations

Cytoplasm.

Diseases

Obesity
Cardiovascular Diseases
Hepatitis
Hepatitis C
Diabetes Mellitus

Pathways

Pathogenesis

PTMs

Phosphorylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NUDT3

References

PMID: 9822604 by Safrany S.T., et al. A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase.

PMID: 10419486 by Safrany S.T., et al. The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein.