Nucleotide triphosphate diphosphatase NUDT15 (NUDT15)

May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (PubMed:22556419, PubMed:26238318).

Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficacy towards these substrates are low. Therefore, the potential in vivo sanitizing role of this receptor, which would consist in removing oxidatively damaged types of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:26238318, PubMed:22556419).