NTHL1 Antibodies

Endonuclease III-like protein 1 (NTHL1)

Bifunctional DNA N-glycosylase with related apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase action releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP website.

Primarily recognizes and fixes oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity.

Gene Information

Human
Gene Name:	NTHL1
Uniprot:	P78549
Entrez:	4913

Family

Belongs to:
Nth/MutY family

Alternative Names

EC 4.2.99.18; endonuclease III-like protein 1; nth endonuclease III-like 1 (E. coli); NTH1; NTHL1; OCTS3; OCTS3NTH1nth (E.coli endonuclease III)-like 1

Molecular Weight

Mass (kDA):
34.39 kDA

Genomic Context

Human
Location:	16p13.3
Sequence:	16; NC_000016.10 (2039820..2047834, complement)

Tissue Specificity

Widely expressed with highest levels in heart and lowest levels in lung and liver.

Subcellular Localizations

Nucleus. Mitochondrion.

Diseases

• Malignant Neoplasms
• Neoplasms
• Sclerosis
• Carcinogenesis
• Tuberous Sclerosis
• Carcinoma
• Colorectal Cancer
• Adenoma
• Adenocarcinoma
• Colorectal Neoplasms
• Dna Injury
• Malignant Neoplasm Of Lung
• Malignant Neoplasm Of Ovary

• Lung Neoplasms
• Cockayne Syndrome
• Tuberous Sclerosis 2 (disorder)
• Cholangiocarcinoma
• Stomach Neoplasms
• Xeroderma Pigmentosum, Group G
• Common Cold

Pathways

• Dna Repair
• Pathogenesis
• Localization
• Cell Adhesion
• Cell Proliferation
• Cell Killing
• Aging
• Proteolysis
• Virulence
• Drug Resistance
• Dna Replication

• Mrna Splicing
• Translation
• Cell Cycle
• Cell Death
• Dna Modification
• Angiogenesis

PTMs

• Oxidation

• Cleavage

• Reduction

Research Areas

• Base Excision Repair
• Cancer
• Chromatin Research
• Core ESC-Like Genes
• DNA Repair

• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NTHL1

What Are the Best Uses of the NTHL1 Marker?

What Are the Best Uses Of The NTHL1 Antibody? This article will discuss the most common uses of the NTHL1 antibody and how to locate it. We will also discuss Steven Boster as well as the risks involved with using this antibody. We will identify NTHL1Antibody and discuss the pAY, risk in unges life, and opmA. These tools are crucial in immunohistochemistry, as well as other biological applications.

pAY = risikofyldte i unges liv

The term "risk" can be used to refer to different risks and threats to an individual’s lives. This term can also be used to describe the consequences of certain types of risk on a person. There are many potential risks associated with different types o arbejdsmiljo. These risks include:

A person's life may be in danger of being ruined if he or she has a young child. Because you never know what the situation could be, a pAY risk assessment can be very helpful. For example, your child might become ill playing. If you are concerned about your child's health, you might consider consulting a psychologist.

This risk assessment is based on sociological definitions of risk. It includes the terms 'deltagelse' and 'fA llesskab.

Industrialisation was the catalyst for the reduction in unges Erhvervs-arbejde. The arbejdskraft grew to be a major component of fabrikker. The industrialization of labour led to the development of hazardous industrial activities.

opmA

opmA is a common antigen and antibody target and is used to detect a specific protein and compound. It is an excellent choice for biological product development because of its high affinity for the target. This antibody has been validated on Western Blotting, Immunohistochemistry, and ELISA platforms. As such, it has been highly cited in scientific literature. Boster Bio is committed to quality assurance and the quality of its products, and offers a variety of high-affinity primary antibodies.

rksomheden

Both humans and mice have the NTHL1 gene. Boster Bio produces antibodies to this gene. These antibodies are highly affine and have been extensively validated in ELISA, WB, and Immunohistochemistry. They are therefore excellent options for NTHL1 research. The question is how best to use these antibodies.

NTHL1 Marker

Nine case-control studies found the NTHL1 mark, ranging in size from the UK Population based Breast Cancer Study to that of the German Consortium for Hereditary Breast and Ovarian Cancer. The cohorts studied include the Hispanic-American Breast Cancer Study, the Australian Breast Cancer Family Registry, the Ontario Familial Birth Cohort, the Dutch Familial Bilateral Breast Cancer Study, and the Quebec Population-based.

Hoogerbrugge, along with colleagues, examined NTHL1 expression in 16 families. They used multiplex immunofluorescent staining to detect the gene. They also used epithelial markers, AE1/AE3, to detect the presence of breast cancer cells. The results indicated that NTHL1 is associated with breast cancer, but the results are not conclusive.

Despite being rare, NTHL1-het tumors are common. In addition, the tumors with NTHL1 expression are similar to those with the wild-type allele, including HRD scores and FGA. This suggests that this gene may have a noncanonical function. The MSK-IMPACT assessment included 22,000 tumors.

These studies also found no evidence that heterozygous NTHL1 loF variants conferred a significant risk for colorectal disease. Further, NTHL1 and MSH3 do not undergo bi-allelic inactivation, which means that there is little risk of colorectal cancer among patients who have them. These tests are able to help with early detection of the disease, and allow for more personalized treatment.