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- Table of Contents
Facts about RNA cytosine C(5)-methyltransferase NSUN2.
May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity.
Mouse | |
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Gene Name: | Nsun2 |
Uniprot: | Q1HFZ0 |
Entrez: | 28114 |
Belongs to: |
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class I-like SAM-binding methyltransferase superfamily |
EC 2.1.1; EC 2.1.1.29; FLJ20303,5-methycytoisine methyltransferase; hTrm4; member 2; Myc-induced SUN-domain-containing protein; NOL1/NOP2/Sun domain family 2; NOL1/NOP2/Sun domain family member 2; NOP2/Sun domain family, member 2; SAKIMisu; Substrate of AIM1/Aurora kinase B; TRM4MISU; tRNA (cytosine-5-)-methyltransferase NSUN2; tRNA (cytosine-5-)-methyltransferase; tRNA methyltransferase 4 homolog
Mass (kDA):
85.452 kDA
Mouse | |
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Location: | 13 C1|13 35.55 cM |
Sequence: | 13; |
Ubiquitously expressed at low level. Up- regulated in tumors.
PMID: 16713953 by Frye M., et al. The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors.
PMID: 19596847 by Hussain S., et al. The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability.