NSD2 Antibodies

Histone-lysine N-methyltransferase NSD2 (NSD2)

Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.

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Gene Information

Human
Gene Name:	NSD2
Uniprot:	O96028
Entrez:	7468

Family

Belongs to:
class V-like SAM-binding methyltransferase superfamily

Alternative Names

EC 2.1.1.43; FLJ23286; IL5 promoter REII region-binding protein; KIAA1090; MGC176638; MMSETNSD2Multiple myeloma SET domain-containing protein; multiple myeloma SET domain containing protein type III; nuclear receptor binding SET domain protein 2; Nuclear SET domain-containing protein 2; probable histone-lysine N-methyltransferase NSD2; Protein trithorax-5; REIIBP; trithorax/ash1-related protein 5; TRX5; WHS; Wolf-Hirschhorn syndrome candidate 1 protein; Wolf-Hirschhorn syndrome candidate 1

Molecular Weight

Mass (kDA):
152.258 kDA

Genomic Context

Human
Location:	4p16.3
Sequence:	4; NC_000004.12 (1871393..1982207)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Nucleus. Chromosome.; [Isoform 4]: Cytoplasm.

Diseases

• Multiple Myeloma
• Wolf-hirschhorn Syndrome
• Malignant Neoplasms
• Neoplasms
• Chromosomal Translocation
• Leukemia
• Tissue Adhesions
• Carcinogenesis
• Cell Transformation, Neoplastic
• Malignant Paraganglionic Neoplasm
• Congenital Abnormality

• Haploinsufficiency
• Leukemia, Plasma Cell
• Craniofacial Abnormalities
• Malignant Neoplasm Of Lung
• Cytogenetic Abnormality

Interacting Proteins

• AR
• MDC1

Pathways

• Methylation
• Pathogenesis
• Cell Growth
• Cell Cycle
• Histone Methylation
• Cell Adhesion
• Cell Proliferation
• Histone Acetylation
• Rna Interference
• Chromatin Remodeling
• Regulation Of Cell Cycle
• Localization
• Epithelial To Mesenchymal Transition

• Demethylation
• Reverse Transcription
• Mrna Splicing
• Translation
• S Phase
• Histone H3-k27 Methylation
• Chromatin Organization

PTMs

• Methylation
• Acetylation

• Phosphorylation
• Demethylation

• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NSD2

Boster Bio - The Best Uses Of The NSD2 Marker

When choosing a primary antibody, there are several different things you can do. Flow procedures can vary widely and Boster Bio's guide can help you determine the best flow procedure for your experiment. A guide can make your experiments more productive. These are some tips that will help you make the most of your NSD2 Marker.

Boster's high affinity primary antibodies

Boster Bio produces a wide range of high-quality, validated antibodies as well as reagents for neuroscience research and immunology research. Boster products have been optimized for use in ELISA/WB applications. Boster products come with a Boster Quality Warranty to ensure maximum reproducibility and productivity. Learn more about the company's neuroscience and immunology antibody range and the many uses they can be applied to.

Monoclonal antibodies from The Goodwin Institute for Cancer Research can also be purchased. Virusys sells these antibodies. Histoline Laboratoires, an Italian antibody company, also sells its antibodies. HyTest manufactures antibodies to be used in a wide variety of research applications. They also create antibody kits to identify different immune systems molecules. Bio-Synthesis is an antibody company that supplies antibodies and reagents to treat autoimmune diseases, infectious diseases and cardiac cell biology.

A high quality primary antibody should be able recognize a target protein with specificity. Specificity is how well the antibody binds the target antigen while minimizing unintended effects. High specificity signifies that the antibody will bind target protein while low specificity means it won’t work with antigens not present in the sample. A good antigen should be able detect, purify and measure the antigen being tested.

Boster has several hundred thousand polyclonal antibody and antibody conjugates. These products can be used in all types diagnostic and basic research. Abbiotec also stocks antigens as well as antibody conjugates. These products can be used for multiplex assays, and they are well-suited for research applications. Alpha Diagnostic International can provide more information. They offer a wide variety of monoclonal antibodies as well as peptides and customer services for contract screening, research, development and research.

In ELISA, matched pairs of capture and detection antibodies are recommended. This is because they can recognize multiple non-overlapping epitopes from the same antigen. The dynamic range and sensitivity may be limited if the same antibody is used for detection and capture. Matching pairs of primary antibodies can reduce cross-reactivity between different types of antibodies.

While having high antigen affinity is a benefit, antibodies can sometimes be too strong for the antigen they are intended to target. They can also be difficult or impossible to separate from antigens. To be freed from the column, they need to be eluted with harsher methods. Boster's high affinity primary antibodies are based on the NSD2 marker. This allows researchers to distinguish similar antigens in different tissues.

History of Steven Boster

If you're interested to learn more about Steve Boster's life, you should start at his birthplace. Boster's rich history includes many historic landmarks. From his first product in 1995 to his later years of being one of the most important catalog antibody companies in China, his history is full of them. Boster also worked in biochemistry early on. His company also developed several ELISA products and the PicoKine(tm), his proprietary platform. This proprietary platform uses trade secrets as well as proprietary technology to deliver high sensitivity ELISA kits.

Don "Steve," Boster, age of 78, was taken from us on June 26, 2022 in Madison, WI. He had been battling COVID-19 for many years. He was the father of Donald, Sr., David Boster, Nina Mae Hall, along with many nieces, nephews, etc. While details about Boster’s life are not available, there are many family members who would love to be able to recall this beloved man.