Neurexin-3-beta Antibodies

Neurexin-3-beta (NRXN3)

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis (By similarity).

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Gene Information

Human
Gene Name:	NRXN3
Uniprot:	Q9HDB5
Entrez:	9369

Family

Belongs to:
neurexin family

Alternative Names

C14orf60; chromosome 14 open reading frame 60; KIAA0743MGC176711; Neurexin 3; neurexin III; Neurexin III-alpha; Neurexin III-beta; neurexin-3-beta; NRXN3

Molecular Weight

Mass (kDA):
69.305 kDA

Genomic Context

Human
Location:	14q24.3-q31.1
Sequence:	14; NC_000014.9 (77979904..79868291)

Tissue Specificity

Expressed in the blood vessel walls (at protein level).

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

• Obesity
• Tissue Adhesions
• Autistic Disorder
• Schizophrenia
• Autism Spectrum Disorders
• Diabetes Mellitus
• Nicotine Dependence
• Carcinoma
• Malignant Neoplasms
• Substance-related Disorders
• Patient Dependence On

• Child Development Disorders, Pervasive
• Cholangiocarcinoma
• Embryonal Carcinoma
• Malignant Neoplasm Of Breast
• Seminoma
• Thyroid Diseases

Pathways

• Cell Adhesion
• Neuroprotection
• Transport
• Intracellular Transport
• Synapse Organization
• Cell-cell Signaling
• Synaptic Transmission
• Neurogenesis
• Inflammatory Response
• Ion Homeostasis
• Cell Death
• Cell Differentiation

• Synapse Assembly
• Social Behavior
• Cognition
• Pathogenesis
• Regulation Of Cyclin-dependent Protein Kinase Activity
• Regulation Of Inflammatory Response

PTMs

• Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NRXN3

Best Uses Of The NRXN3 Marker

Anti-Neurexin-3-beta NRXN3 Marker is a primary antibody with high affinity made by Boster Bio. This article will go over the most widely used applications of this product. These applications are used by scientists worldwide. The Boster Bio NRXN3 Marker is a highly specific and high-affinity antigen that can be utilized for numerous biological research applications.

Boster Bio's Antineurexin-3-beta Marker

The Neurexin-3 beta (NRXN3) protein is part of the neurexin family. It is found in the brain and binds postsynaptic Neuroligins 1 and 3. It is also found in non-nervous tissues. It is subject to polymorphisms that affect the splicing pattern. Certain polymorphisms are associated with alcohol dependence.

Neurexins 1-3, transmembrane neuronal Glycoproteins are transcribed from three NRXN gene. Neurexin 3 beta only has one LNS domain and has no EGF-like domain. The protein also contains a PDZ scaffolding motif. The human and mouse Neurexin 3 beta proteins have 99% sequence similarity.

BosterBio's high affinity primary antibody

The anti-NRXN3 antigen from BosterBio was designed to recognize the Neurexin 3 (NRXN3) marker, a key protein involved in the immune system. It is tested for Western Blot applications and reacts with both Human and Mouse antibodies. The primary antibody with high affinity is extremely specific and has excellent cross-reactivity to other proteins.

Next-generation sequencing permits the reconstruction of antibody clonal linesages including their germ line progenitors. Although germ line sequences may not be exactly like an unmutated ancestral lineage, they are very useful for the detection of mutations. Mutations of VL and VH gene segments can be detected with high confidence, while original VLJL and VHDJH junctional sequences are inconclusive. It is also essential to know if there were any deletions or additions to affinity maturation.

During immune responses the antibody's affinity nitrophenyl phosphonate increases by up to 3000-fold. Its affinity for nitrophenylphosphonate increases over time. The antibody recognizes a tiny hapten and is extremely specific to it. Somatic mutations in CDR residues enhance the antibody's affinity, which results in an increase in hydrogen bonds, electrostatic interactions, and van der Waals interactions.

High-affinity antibodies are crucial for immune protection and development occurs in germinal centers. These histologic structures originate from clusters of proliferating B cells. They work together with signals from T cells and antigen-presenting cell to generate high-affinity antibodies. Through this process, antibodies are created by mutation and selection. The resulting antibodies are tested against previously produced antibodies and unmutated antigen receptors.

This antibody also targets the trimeric Env. This allows it to increase its binding domain below the glycan barrier. These two attributes make it a superior antigen-recognition antibody. The antibodies can recognize both gp120 and Glycans. The antibody is developed for the recognition of both proteins as well as their effective neutralization.

Additional interactions with antigens help in the maturation of affinity anti NRXN3 antigens. The HIV-1 envelope glycoprotein's germ line precursor antibody CH58 interacts directly with the V2 peptide. It is located close to the Lys169 element. The V2 peptide binds to VL, leading to an affinity maturation of around 2000-fold.

The most commonly used uses

The NRXN3 gene has been identified using the analysis of genomic sequence. It has two exons, and one intron. The gene is 1.6 Mb. It has numerous stop codons, and is highly splicing different. The exons that contain the initial LNS domain and the first EGF-like repeat are more than two kb long. The remaining exons are comprised of at least one intron. The last exon codes for the transmembrane region and the cytoplasmic tail.

Low NRXN3 levels are associated with an increased chance of developing Alzheimer's disease (AD). More research is needed to determine the cause of this association. Because AD develops over a period of time before it is diagnosed, the preclinical phase of AD is lengthy. These changes can lead to the brain ageing. Normal aging is an event in which the brain experiences constant changes in shape, size or vasculature. This increases the likelihood of triggers that cause disease, and may also aggravate pre-existing conditions.

The NRXN3 gene is associated with various genes. It plays a key role in nerve cell activity and the function of synapse. In addition, NRXN3 is linked to NLGN1 and NLGN2., as well as NLGN3.

NRXN3 expression is seen in neurons. It can be studied using reverse transcription polymerase chain reaction and the RNA sequencing. RNA samples from brain regions that have higher levels of NRXN3 are not detected in substantial quantities. They could be susceptible to nonsense-mediated mRNA decay. Most of these mRNAs can be found at low levels in the cells.

Neurexins are cell adhesion molecules within the nervous system. NRXN3 isoforms are created by splicing genes for neurexin. The neuroexins of the a- and b-type are mainly membrane-bound, whereas the soluble neurexins are produced by a variety of promoters that are used in different ways. In certain instances spider neurotoxins are capable of binding to neuroligins with membrane-bound binders.