Pro-neuregulin-4, membrane-bound isoform (Nrg4)

Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors.

Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. .