NR5A2 Antibodies

Nuclear receptor subfamily 5 group A member 2 (NR5A2)

Nuclear receptor that acts as a key metabolic sensor by modulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Along with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism.

Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a crucial cis-element of their expression and regulation.

Gene Information

Human
Gene Name:	NR5A2
Uniprot:	O00482
Entrez:	2494

Family

Belongs to:
nuclear hormone receptor family

Alternative Names

Alpha-1-fetoprotein transcription factor; B1-binding factor; b1-binding factor, hepatocyte transcription factor which activates enhancer IIof hepatitis B virus; B1F; B1F2; fetoprotein-alpha 1 (AFP) transcription factor; FTFLRH1; FTZ-F1 beta; FTZ-F1; FTZ-F1beta; HB1F; hB1F-2; hB1FCYP7A promoter-binding factor; Hepatocytic transcription factor; Liver receptor homolog 1; liver receptor homolog-1; LRH1; LRH-1; LRH-1CPF; NR5A2; nuclear receptor NR5A2; nuclear receptor subfamily 5 group A member 2; nuclear receptor subfamily 5, group A, member 2

Molecular Weight

Mass (kDA):
61.331 kDA

Genomic Context

Human
Location:	1q32.1
Sequence:	1; NC_000001.11 (200027710..200177424)

Tissue Specificity

Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells.

Subcellular Localizations

Nucleus.

Diseases

• Malignant Neoplasms
• Neoplasms
• Malignant Neoplasm Of Breast
• Pituitary Diseases
• Carcinoma
• Mammary Neoplasms
• Hepatitis B
• Hepatitis
• Liver Carcinoma
• Inflammation
• Cell Transformation, Neoplastic
• Malignant Neoplasm Of Pancreas
• Pancreatic Neoplasm

• Adenocarcinoma
• Liver Diseases
• Insulin Resistance
• Liver Neoplasms
• Carcinogenesis
• Diabetes Mellitus
• Infertility

Interacting Proteins

• CTNNB1
• EDF1
• NCOA2
• NR0B2
• PROX1

Pathways

• Cholesterol Homeostasis
• Transport
• Cell Proliferation
• Cell Differentiation
• Localization
• Cholesterol Transport
• Reverse Cholesterol Transport
• Rna Interference
• Ovulation
• Cell Cycle
• Secretion
• Pathogenesis
• Granulosa Cell Differentiation

• Regulation Of Gene Expression
• Conjugation
• Lipid Homeostasis
• Regeneration
• Glycolysis
• Inflammatory Response
• Gastrulation

PTMs

• Cleavage
• Sumoylation
• Phosphorylation

• Acetylation
• Demethylation
• Methylation

• Deacetylation

Research Areas

• Chromatin Research
• Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NR5A2

Boster Bio - Best Uses Of The NR5A2 Marker

If you're looking to determine if your gene expression is normal or abnormal, you can find more about this gene by reading this infographic on the gene from Boster Bio. This marker is useful for detecting the NR5A2 genes. Boster can submit its results to earn product credits. You can send your results to Boster to receive product credits. This marker is available to all scientists worldwide.

Boster's anti NR5A2 marker

The scientific community is able to use the Boster's antiNR5A2-Marker for a variety of purposes. The antibody has been tested for reactivity to mouse, rat and specific species-specific antibodies. It can be used to analyze a broad range of samples including liver, kidney, and fetal tissues. Boster provides anti-NR5A2-Marker to your lab for specific species-specific applications.

The results revealed that Rarg and Nr5a2 increased the percentage of multipolar neuronal cells. Both proteins significantly increased the number of dendritic branches as well as the length in total. These proteins also accelerate dendritic arborization, as per the cumulative distribution analysis. Both molecules also enhanced dendritic complexity. Furthermore, the researchers found that activation of Rarg and Nr5A2 speed up dendritic formation in cells in culture.