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- Table of Contents
Facts about Nuclear receptor subfamily 1 group D member 2.
Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory reaction. Acts as a receptor for heme which arouses its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression.
Human | |
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Gene Name: | NR1D2 |
Uniprot: | Q14995 |
Entrez: | 9975 |
Belongs to: |
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nuclear hormone receptor family |
BD73; EAR-1R; HZF2; NR1D2; nuclear receptor subfamily 1 group D member 2; nuclear receptor subfamily 1, group D, member 2; Orphan nuclear hormone receptor BD73; Reverb beta; Rev-erb beta; rev-erba-alpha-related receptor; rev-erb-beta; RVR; V-erbA-related protein 1-related
Mass (kDA):
64.625 kDA
Human | |
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Location: | 3p24.2 |
Sequence: | 3; NC_000003.12 (23945286..23980618) |
Widely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues.
Nucleus. Cytoplasm. Phosphorylation by CSNK1E enhances its cytoplasmic localization.
PMID: 7997240 by Dumas B., et al. A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb.
PMID: 11113208 by Sauve F., et al. CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant.