NPR1 Antibodies

Atrial natriuretic peptide receptor 1 (NPR1)

Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.

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Gene Information

Human
Gene Name:	NPR1
Uniprot:	P16066
Entrez:	4881

Family

Belongs to:
adenylyl cyclase class-4/guanylyl cyclase family

Alternative Names

ANPa; ANP-A; ANPRA; ANPR-A; ANPRAEC 4.6.1.2; atrial natriuretic peptide receptor 1; Atrial natriuretic peptide receptor type A; atrionatriuretic peptide receptor A; GC-A; Guanylate cyclase A; GUC2A; GUCY2A; natriuretic peptide A type receptor; natriuretic peptide receptor A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptidereceptor A); NPR1; NPRA; NPR-A; Pndr

Molecular Weight

Mass (kDA):
118.919 kDA

Genomic Context

Human
Location:	1q21.3
Sequence:	1; NC_000001.11 (153678649..153693992)

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

• Plant Diseases
• Hypertrophy
• Hypertensive Disease
• Cardiac Hypertrophy
• Fibrosis
• Infective Disorder
• Infectious Bovine Keratoconjunctivitis
• Physiological Stress
• Heart Failure
• Dwarfism
• Cell Invasion
• Bacterial Infections

• Virus Diseases
• Malignant Neoplasms
• Asiderotic Anemia
• Neoplasms
• Cardiovascular Diseases
• Heavy Chain Disease

Pathways

• Systemic Acquired Resistance
• Disease Resistance
• Cell Death
• Defense Response
• Localization
• Pathogenesis
• Immune Response
• Induced Systemic Resistance
• Transport
• Gene Silencing
• Programmed Cell Death
• Virulence
• Senescence

• Germination
• Secretion
• Endocytosis
• Cell Growth
• Excretion
• Hypersensitivity
• Methylation

PTMs

• Phosphorylation
• Dephosphorylation
• Ubiquitination
• Nitrosylation
• Methylation

• Reduction
• Nitration
• Cleavage
• Acetylation
• Oxidation

• Farnesylation

Research Areas

• Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NPR1

Best Uses Of The NPR1 Marker

The NPR1 Marker is best used in the same manner as other fluorescent proteins. Reconstitution of the fluorescence derived from YFP is possible through the AV2-SlCat2 interactions. If you're interested in learning more about Steven Boster and his research take a look at. We also go over his research and background. Read on for his bio as well as some of the best uses of the NPR1 Marker.

Reconstitution of YFP fluorescence is possible via the AV2-SlCat2 interaction

YFP expression was reconstituted through the Fusion of the AV2 gene and segments from SlCat2 or Cat2 (AC4HA). The fusions led to significant YFP signals in the cytoplasm and along cell margins. SlOEEcYFP did not produce a signal of fluorescence. This was consistent with previous reports that demonstrated that the AV2-SlCat2 interactions result in the reconstitution YFP fluorescence inside the cells.

These results suggest that the AV2-SlCat2 interaction results in the reconstitution YFP fluorescence. This model suggests that the AV2 molecule interacts and transfers excited-state energy from the acceptor to form SlCat2. The donor fluorophore undergoes this process without emitting photons, resulting in a fluorescence-sensitized emission that is similar to that of the acceptor.

Viruses that cause plant lysis are capable of inhibiting the hypersensitive response , causing the death of cells programmed. Plant cells undergo physiological change upon viral invasion. These include the generation of ROS, activation hormone signalling pathways as well as localized PCD. Systemic necrosis could also be caused by transient expressions of AV2 protein from N. benthamiana. Additionally, this necrosis phenotype is associated with changes in the expression of genes that are related to defence.

Reconstitution of YFP fluorescence can be achieved through the AV2-SlCat2 connection in yeast strains. These mutant strains possess the ability to inhibit YFP fluorescence. Moreover, AV2-SlCat2 interaction is mediated by a transactivation-insensitive gene, and the result is reconstitution of YFP fluorescence.

The activation of the SA signalling pathway may result in the decrease in the transcription of AV2-SlCat2. This could be the result of the deregulation of the EDS1 gene. To cause viral infection, AV2 is thought to target a host protein which is Cat2. In addition, AV2-SlCat2 interaction causes a reduction in Cat2 expression. This increases the synthesis rate of SA which results in a depleting environment. It also causes the an accumulation of YFP positive RNA and YFP fluorescent.

BiFC offers a method of studying protein-protein interactions in the living. The BiFC method permits bimolecularly purified fluorescent proteins to be reconstituted from split fragments. The two proteins have fluorescent in different locations within the cell and can be joined through bimolecular fluorescence complementation. This technique also permits the identification of non-target proteins.

The protein interactions between AV2-SlCat2 result in the reconstituted YFP fluorescence. Hox proteins are involved in interactions with many transcription factors. This study is important in understanding the role played by AV2 in the process of viral DNA movement. It has demonstrated that AV2 is an important role in the systemic movement of viral DNA-A in plants. Furthermore, the study shows that the catalase protein is required for the translocation of viral DNA-A from cell to.

The presence of agrobacterium-mediated inoculation in N. benthamiana plant inoculated with DNA-A+DNA-B was essential for downward leaf curling, epinasty, and interveinal chlorosis. AV2 is also important in viral replication , as evident by its high expression levels in the plant tissues.

The story of Steven Boster's past

You can easily discover the entire history of Steven Boster by accessing his public records. His public records include his current address, past addresses and mobile phone numbers, email addresses, and his home number. He was also a well-known and well-known relative to many. To find out more information about Steve Boster, you can filter your results by state. You can also check out the past addresses of Steve Boster to avoid over-searching for information that is not relevant.

The Boster family and friends will remember Steve Boster's existence after his passing. There aren't any scheduled funeral services or memorial events to honor his memory. If you'd like to pay tribute to Steve you can send flowers or plant a tree in his honor. Concordia Hall is the perfect venue to pay tribute. To plant the tree in his memory you can use the following information:

His current research

His research was built on the discovery of SAR which is essential to activate NLS (nuclear localization signal) in NPR1. Translocation into the nucleus of the receptor results in nuclear localization and subsequent redox modification. This mechanism offers a variety of possibilities for understanding of cancer. It could be used to attack cancer cells. However it requires the redox-modifying enzyme.