NPEPPS Antibodies

AND NPEPPS ELISA kits, NPEPPS Proteins

Many biological assays use antibodies to detect NPEPPS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NPEPPS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NPEPPS antibodies...

We validate the specificity of these antibodies to NPEPPS by testing them on tissues known to express NPEPPS positively and negatively. Browse below to find the NPEPPS antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NPEPPS Infographic by Boster Bio

All NPEPPS Products

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Product

Figures

Specificity

Applications

Price

NPEPPS (NM_006310) Human Over-expression Lysate

Human

$960
Cat # LS009520
100 µg

Anti-NPEPPS Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A08129-2
100 µg/vial

NPEPPS Overview

Facts about Puromycin-sensitive aminopeptidase.

NPEPPS 3D structure. Source: alphafold

Puromycin-sensitive aminopeptidase (NPEPPS)

Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability.

Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors.

Gene Information

Human
Gene Name:	NPEPPS
Uniprot:	P55786
Entrez:	9520

Family

Belongs to:

peptidase M1 family

Alternative Names

AAP-S; aminopeptidase puromycin sensitive; Cytosol alanyl aminopeptidase; EC 3.4.11.2; EC 3.4.11.3; metalloproteinase MP100; MP100; MP100EC 3.4.11; NPEPPS; PSAEC 3.4.11.14; puromycin-sensitive aminopeptidase

Molecular Weight

Mass (kDA):
103.276 kDA

Genomic Context


Human

Location:	17q21.32
Sequence:	17; NC_000017.11 (47522933..47623276)

Tissue Specificity

Detected in liver, epithelium of renal tubules, epithelium of small and large intestine, gastric epithelial cells, and alveoli of the lung (at protein level).

Subcellular Localizations

Cytoplasm, cytosol. Nucleus.

Diseases

Nerve Degeneration
Tauopathies
Alzheimer's Disease
Sclerosis
Neuroblastoma
Gliosis
Primary Lateral Sclerosis
Neurodegenerative Disorders
Dementia
Amyotrophic Lateral Sclerosis

Malignant Neoplasms
Nervousness
Neuropathology Disease
Impaired Cognition
Neurofibrillary Tangles

Pathways

Proteolysis
Localization
Cell Death
Pathogenesis

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NPEPPS

References

PMID: 9048733 by Tobler A.R., et al. Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons.

PMID: 11435692 by Bauer W.O., et al. Human puromycin-sensitive aminopeptidase: cloning of 3' UTR, evidence for a polymorphism at a.a. 140 and refined chromosomal localization to 17q21.