NADPH oxidase activator 1 Antibodies

NADPH oxidase activator 1 (NOXA1)

Functions as an activator of NOX1, a superoxide- generating NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction.

May also activate CYBB/gp91phox and NOX3. .

Gene Information

Human
Gene Name:	NOXA1
Uniprot:	Q86UR1
Entrez:	10811

Family

Belongs to:
NCF2/NOXA1 family

Alternative Names

Antigen NY-CO-31; FLJ25475; inhibitory NADPH oxidase activator 1; MGC131800; NADPH oxidase activator 1; NCF2-like protein; NOX activator 1; NY-CO-31; p51NOX; p51-nox; P67phox-like factor; SDCCAG31; serologically defined colon cancer antigen 31

Molecular Weight

Mass (kDA):
50.933 kDA

Genomic Context

Human
Location:	9q34.3
Sequence:	9; NC_000009.12 (137423372..137434406)

Tissue Specificity

Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.

Subcellular Localizations

Cytoplasm. Cell membrane. Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.

Diseases

• Malignant Neoplasms
• Neoplasms
• Malignant Tumor Of Colon
• Hypoxia
• Carcinoma
• Fibrosis
• Tumor Angiogenesis
• Inflammation
• Colonic Neoplasms
• Cardiovascular Diseases
• Anoxia
• Atherosclerosis
• Hypertensive Disease

• Vascular Diseases
• Dyslipidemias
• Ataxia
• Hepatitis C, Chronic
• Neoplasm Invasiveness
• Injury To Liver
• Posttransfusion Purpura

Interacting Proteins

• RIMBP3

Pathways

• Localization
• Cell Death
• Phagocytosis
• Cell Proliferation
• Pathogenesis
• Respiratory Burst
• Transport
• Angiogenesis
• Secretion
• Cell Adhesion
• Protein Phosphorylation
• Cell Activation
• Hyperphosphorylation

• Proteolysis
• Immune Response
• Pigmentation
• Superoxide Anion Generation
• Regulation Of Lipid Binding
• Reverse Transcription
• Translation

PTMs

• Phosphorylation
• Glycosylation

• Acetylation
• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NOXA1

Best Uses Of The NOXA1 Marker

What are the Best Uses of The NOXA1 Gene Test Test? There are several genes involved in the development of cancer. These genes include KRAS/G12V/D as well as HER2/G776/YVMA, E545K and HER2/G776. This article covers them all. However, if you have a particular gene, you can look for a specific gene expression profile for it.

KRAS/G12V/D

The NOXA1 superfamily member is a unique one. It binds the NoxA1 Nterminal proline rich region. Although NoxA1 can be found in most cells it is not well understood. The NOXA1 gene was expressed in many tissues and types of cells to study its distribution. Here are some examples of how this marker is used.

This enzyme is involved with normal physiological functions and immune responses. It also plays a role in vascular disorders, impaired immune systems, and bacterial as well as viral infections. It is therefore important that we understand how NOX works, and the various pathways through which it mediates. Understanding the function of NOX can help improve tissue repair time and better withstand stress. NOX family members have been implicated in a variety of diseases and conditions.

The regulation of vascular function is regulated by the NOXA1 genes. It acts as a critical limiting factor for NOX1 activation, and regulates Na+ retention in AIH cells. The NOXA1 genome has been linked with vascular disease in kidneys. However it is unknown how it plays a role in AIH. The NOXA1 genetic variant is well-suited for further research.

HER2/G776(YVMA), HER2/E545K

The NOXA1 marker is one of the most frequently detected tumor markers. It is more common in patients with cancers related to the BRAF (NRAS), HRAS, HRAS (or G9D) genes. It is extremely useful in the early detection and treatment of cancer, particularly pancreatic cancer. However, it is not clear how this marker may be used for diagnostic purposes.