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NOTCH4 Antibodies
AND NOTCH4 ELISA kits, NOTCH4 Proteins
Many biological assays use antibodies to detect NOTCH4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NOTCH4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NOTCH4 antibodies...
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NOTCH4 Overview
Facts about Neurogenic locus notch homolog protein 4.
Neurogenic locus notch homolog protein 4 (NOTCH4)
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate conclusion. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing circulatory system (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | NOTCH4 |
| Uniprot: | Q99466 |
| Entrez: | 4855 |
Family
| Belongs to: |
|---|
| NOTCH family |
Alternative Names
INT3; neurogenic locus notch homolog protein 4; notch 4; Notch homolog 4; NOTCH3; Notch4; Notch-4
Molecular Weight
Mass (kDA):
209.622 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.32 |
| Sequence: | 6; NC_000006.12 (32194843..32224067, complement) |
Tissue Specificity
Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.; [Notch 4 intracellular domain]: Nucleus. Following proteolytical processing NICD is translocated to the nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Schizophrenia
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Tumor Angiogenesis
- Dysequilibrium Syndrome
- Malignant Neoplasm Of Breast
- Leukemia
- Cerebrovascular Accident
- Arteriopathic Disease
- Leukoencephalopathies
Pathways
- Notch Signaling Pathway
- Angiogenesis
- Pathogenesis
- Cell Differentiation
- Cell Proliferation
- Cell Cycle
- Localization
- Gland Development
- Mammary Gland Development
- Cell Growth
- Cell Development
- Cell Fate Determination
- Methylation
PTMs
- Cleavage
- Phosphorylation
- Methylation
Research Areas
- Angiogenesis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NOTCH4
bosterbio.com/bosterbio-gene-info-cards/NOTCH4
References
PMID: 9168133 by Sugaya K., et al. Gene organization of human NOTCH4 and (CTG)n polymorphism in this human counterpart gene of mouse proto-oncogene Int3.
PMID: 9693032 by Li L., et al. Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene.