NOTCH3 Antibodies

AND NOTCH3 ELISA kits, NOTCH3 Proteins

Many biological assays use antibodies to detect NOTCH3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NOTCH3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NOTCH3 antibodies...

We validate the specificity of these antibodies to NOTCH3 by testing them on tissues known to express NOTCH3 positively and negatively. Browse below to find the NOTCH3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NOTCH3 Infographic by Boster Bio

All NOTCH3 Products

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Product

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Specificity

Applications

Price

Anti-NOTCH3 Antibody

Human, Mouse, Rat

$405
Cat # A00485-1
100ul

Human NOTCH3 ELISA Kit PicoKine®

Human

ELISA

$499
Cat # EK2275
96 wells/kit, with removable strips.

NOTCH3 Overview

Facts about Neurogenic locus notch homolog protein 3.

NOTCH3 3D structure. Source: alphafold

Neurogenic locus notch homolog protein 3 (NOTCH3)

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.

Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). .

Gene Information

Human
Gene Name:	NOTCH3
Uniprot:	Q9UM47
Entrez:	4854

Family

Belongs to:

NOTCH family

Alternative Names

CADASIL; CASILneurogenic locus notch homolog protein 3; Notch (Drosophila) homolog 3; notch 3Notch homolog 3 (Drosophila); Notch homolog 3; Notch3; Notch-3

Molecular Weight

Mass (kDA):
243.631 kDA

Genomic Context


Human

Location:	19p13.12
Sequence:	19; NC_000019.10 (15159038..15200995, complement)

Tissue Specificity

Ubiquitously expressed in fetal and adult tissues.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.; [Notch 3 intracellular domain]: Nucleus. Following proteolytical processing NICD is translocated to the nucleus.