NOTCH2 Antibodies

Neurogenic locus notch homolog protein 2 (NOTCH2)

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to modulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989).

Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis.

Gene Information

Human
Gene Name:	NOTCH2
Uniprot:	Q04721
Entrez:	4853

Family

Belongs to:
NOTCH family

Alternative Names

AGS2; hN2; neurogenic locus notch homolog protein 2; Notch (Drosophila) homolog 2; notch 2Notch homolog 2 (Drosophila); Notch homolog 2; Notch2; Notch-2

Molecular Weight

Mass (kDA):
265.405 kDA

Genomic Context

Human
Location:	1p12
Sequence:	1; NC_000001.11 (119911553..120069703, complement)

Tissue Specificity

Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.

Subcellular Localizations

[Notch 2 extracellular truncation]: Cell membrane; Single-pass type I membrane protein.; [Notch 2 intracellular domain]: Nucleus. Cytoplasm. Following proteolytical processing NICD is translocated to the nucleus. Retained at the cytoplasm by TCIM (PubMed:25985737).

Diseases

• Neoplasms
• Malignant Neoplasms
• Cell Transformation, Neoplastic
• Leukemia
• Alagille Syndrome
• Carcinoma
• Malignant Paraganglionic Neoplasm
• Diabetes Mellitus
• Diabetes Mellitus, Non-insulin-dependent
• Lymphoma
• Brain Neoplasms
• Hyperplasia
• Malignant Neoplasm Of Breast

• Nervousness
• Adenocarcinoma
• Glioma
• Glioblastoma
• Medulloblastoma
• Mammary Neoplasms
• Cell Invasion

Pathways

• Notch Signaling Pathway
• Cell Differentiation
• Cell Proliferation
• Pathogenesis
• Cell Cycle
• Cell Development
• Cell Fate Determination
• Localization
• Regeneration
• Neurogenesis
• Cell Growth
• Cell Fate Specification
• Cell Death

• Secretion
• Segmentation
• Brain Development
• Angiogenesis
• Rna Interference
• Cell Cycle Arrest
• Cell Migration

PTMs

• Cleavage
• Phosphorylation
• Hydroxylation

• Glycosylation
• Phosphorothioation
• Acetylation

• Methylation

Research Areas

• Apoptosis
• Cancer
• Golgi Apparatus Markers
• Growth and Development
• Neuronal Cell Markers

• Signal Transduction
• Stem Cell Signaling Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NOTCH2

Best Uses of the Notch2 Marker

The Notch2 Marker is an inhibitor of tumor growth and can regulate cell fate during development. It also recruits coactivators. Scientists and researchers are able to submit their research results in order to receive product credit and special samples. They can also submit results for species and applications and get product credits. These benefits are available for researchers around the world. Here are some of the best uses for the NOTCH2 marker.

Notch2 Marker acts as a tumor suppressor

Early invasive growth in gliomas is a major reason for poor therapeutic outcomes. GSCs preferentially reside in white matter tracts. Jagged1 expression is elevated on Notch ligands. SOX2, a Notch-induced transcription factor Sox9, promotes transcription of SOX2, which strengthens Notch2 expression. SOX2 overregulation reduces NOTCH9 and inhibits Notch signaling.

The first step of RT-PCR involved extracting total RNA using a kit that includes miR-34a. The Super M-MLV reverse transcriptionase was used to process the RNA. The second step consisted of preparing the reaction mixture. The second step was to prepare the reaction mixture.

It reduces proliferation

The progression of many cancers has been linked to Polo-like Kinase 1. Its high expression is associated with poor prognosis. Inhibition of p53, a major tumor suppressor, is one of its main functions. PLK1 blocks p53 through inhibiting its family members, such as p63 or p73. It also prevents the proliferation of cancer-cells by activating apoptosis.