NOTCH1 Antibodies

AND NOTCH1 ELISA kits, NOTCH1 Proteins

Many biological assays use antibodies to detect NOTCH1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NOTCH1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NOTCH1 antibodies...

We validate the specificity of these antibodies to NOTCH1 by testing them on tissues known to express NOTCH1 positively and negatively. Browse below to find the NOTCH1 antibody that suites your experiment. We have 9 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NOTCH1 Infographic by Boster Bio

All NOTCH1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Notch1 Antibody Picoband®

1 Citations 16 Q&As

Human

$370
Cat # PA1215
100 μg/vial

Anti-NOTCH 1 Antibody

14 Q&As

Human, Mouse

Dot blot, ELISA, IHC, WB

$629
Cat # A00033
200uL

Anti-Cleaved-Notch 1 (V1754) Antibody

15 Q&As

Human, Mouse, Rat

$399
Cat # A00033-1
100μl

Anti-Notch1 Antibody Picoband®

1 Citations 15 Q&As

Human, Mouse

$370
Cat # A00033-2
100 μg/vial

Human NOTCH1 / TAN 1 ELISA Kit PicoKine®

5 Q&As

Human

ELISA

$499
Cat # EK1619
96 wells/kit, with removable strips.

Anti-Notch1 Monoclonal Antibody

1 Citations 16 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M00033
100 μl

Anti-Cleaved-Notch 1 (V1754) Antibody

Human, Mouse, Rat

IHC

$405
Cat # A00033-4
100ul

Anti-(Mouse) Notch1 Antibody (C-term)

Mouse

$299
Cat # M00033-1
80 µl

NOTCH1 (NM_017617) Human Over-expression Lysate

Human

$960
Cat # LS004851
100 µg

NOTCH1 Overview

Facts about Neurogenic locus notch homolog protein 1.

NOTCH1 3D structure. Source: alphafold

Neurogenic locus notch homolog protein 1 (NOTCH1)

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.

Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus.

Gene Information

Human
Gene Name:	NOTCH1
Uniprot:	P46531
Entrez:	4851

Family

Belongs to:

NOTCH family

Alternative Names

EC 2.1.2.11; EC 3.4.21.68; hN1; Notch (Drosophila) homolog 1 (translocation-associated); notch 1Notch homolog 1, translocation-associated (Drosophila); Notch homolog 1, translocation-associated; Notch1; Notch-1; TAN1; TAN1neurogenic locus notch homolog protein 1; Translocation-associated notch protein TAN-1

Molecular Weight

Mass (kDA):
272.505 kDA

Genomic Context


Human

Location:	9q34.3
Sequence:	9; NC_000009.12 (136494433..136546048, complement)

Tissue Specificity

In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.; [Notch 1 intracellular domain]: Nucleus. Following proteolytical processing NICD is translocated to the nucleus. Nuclear location may require MEGF10.

Diseases

Neoplasms
Malignant Neoplasms
Leukemia
Precursor T-cell Lymphoblastic Leukemia-lymphoma
Cell Transformation, Neoplastic
Acute Lymphocytic Leukemia
Carcinoma
Lymphoma
Nervousness
Tumor Angiogenesis
Malignant Paraganglionic Neoplasm
Malignant Neoplasm Of Breast
Mammary Neoplasms

Alzheimer's Disease
Neoplasm Metastasis
Adult T-cell Lymphoma/leukemia
Leukemogenesis
Leukemia, T-cell
Hyperplasia
Cell Invasion

Interacting Proteins

ATM
FBXW7
HIF1A
JAG1
KDM1A

LILRB2
MAML1
NFKB1
PIN1
RBPJ

SNW1
XIAP

Pathways

Notch Signaling Pathway
Cell Proliferation
Cell Differentiation
Pathogenesis
Cell Cycle
Cell Growth
Neurogenesis
Cell Development
Angiogenesis
Localization
Cell Fate Determination
Cell Death
Regeneration

Proteolysis
Cell Cycle Arrest
Rna Interference
Secretion
Oncogenesis
Cell Migration
Somitogenesis

PTMs

Cleavage
Phosphorylation
Methylation
Ubiquitination
Glycosylation
Acetylation
Hydroxylation
Reduction

Biotinylation
Demethylation
Gamma-cleavage
Dephosphorylation
Ubiquitinylation
Nitration
Farnesylation
Deacetylation

Oxidation

Research Areas

Cancer Stem Cells
Golgi Apparatus Markers
Growth and Development
Neuronal Cell Markers
Neuroscience

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NOTCH1

References

PMID: 1831692 by Ellisen L.W., et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.

PMID: 17573339 by Coleman M.L., et al. Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.

2 Publications of Boster NOTCH1 Antibodies & ELISA Kits

PubMed ID: 28713967, Involvement of Notch2 in all%u2011trans retinoic acid%u2011induced inhibition of...
PubMed ID: 25536154, Mi L, Chen Y, Zheng X, Li Y, Zhang Q, Mo D, Yang G. J Cell Biochem. 2015 Jul;116...

*More publications can be found for each product on its corresponding product page