NMRAL1 Antibodies

AND NMRAL1 ELISA kits, NMRAL1 Proteins

Many biological assays use antibodies to detect NMRAL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NMRAL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NMRAL1 antibodies...

We validate the specificity of these antibodies to NMRAL1 by testing them on tissues known to express NMRAL1 positively and negatively. Browse below to find the NMRAL1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NMRAL1 Infographic by Boster Bio

All NMRAL1 Products

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Price

NMRAL1 (NM_020677) Human Recombinant Protein

$813
Cat # PROTQ9HBL8
20 µg

NMRAL1 (NM_020677) Human Over-expression Lysate

Human

$628
Cat # LS057407
100 µg

NMRAL1 Overview

Facts about NmrA-like family domain-containing protein 1.

NMRAL1 3D structure. Source: alphafold

NmrA-like family domain-containing protein 1 (NMRAL1)

Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels.

At low NADPH concentrations the protein is found mainly as a monomer, also binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its action and reduces the production of nitric oxide, which subsecuently prevents apoptosis.

Gene Information

Human
Gene Name:	NMRAL1
Uniprot:	Q9HBL8
Entrez:	57407

Family

Belongs to:

NmrA-type oxidoreductase family

Alternative Names

HSCARGFLJ25918; NmrA-like family domain containing 1; nmrA-like family domain-containing protein 1; SDR48A1; short chain dehydrogenase/reductase family 48A, member 1

Molecular Weight

Mass (kDA):
33.344 kDA

Genomic Context


Human

Location:	16p13.3
Sequence:	16; NC_000016.10 (4461680..4476337, complement)

Subcellular Localizations

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios.

Diseases

Malignant Neoplasms

Interacting Proteins

ASS1

Pathways

Mrna Transcription
Proteolysis
Cell Growth
Nuclear Export

PTMs

Phosphorylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NMRAL1

References

PMID: 18263583 by Zhao Y., et al. An NADPH sensor protein (HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability.

PMID: 17496144 by Zheng X., et al. Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein.