NACHT, LRR and PYD domains-containing protein 4 (NLRP4)

May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by functioning as an adapter to market DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation.

Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it functions at a point of convergence in both of these cytokine signaling pathways. .