NLRP2 Antibodies

AND NLRP2 ELISA kits, NLRP2 Proteins

Many biological assays use antibodies to detect NLRP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NLRP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NLRP2 antibodies...

We validate the specificity of these antibodies to NLRP2 by testing them on tissues known to express NLRP2 positively and negatively. Browse below to find the NLRP2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NLRP2 Infographic by Boster Bio

All NLRP2 Products

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Product

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Specificity

Applications

Price

Anti-NALP2/NLRP2 Antibody Picoband®

1 Q&As

Human, Mouse, Rat

ELISA, WB

$370
Cat # A04819-2
100 μg/vial

NALP2 (NLRP2) (NM_017852) Human Recombinant Protein

$1062
Cat # PROTQ9NX02
20 µg

NALP2 (NLRP2) (NM_017852) Human Over-expression Lysate

Human

$628
Cat # LS055655
100 µg

Anti-NLRP2 Antibody Picoband®

Human

ELISA, Flow Cytometry, IP, IF, ICC, WB

$370
Cat # A04819-3
100 μg/vial

NLRP2 Overview

Facts about NACHT, LRR and PYD domains-containing protein 2.

NLRP2 3D structure. Source: alphafold

NACHT, LRR and PYD domains-containing protein 2 (NLRP2)

Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF.
When connected with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B.

May be a part of the inflammasome, a protein complex that also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. .

Gene Information

Human
Gene Name:	NLRP2
Uniprot:	Q9NX02
Entrez:	55655

Family

Belongs to:

NLRP family

Alternative Names

CLR19.9; FLJ20510; NACHT, leucine rich repeat and PYD containing 2; NACHT, LRR and PYD domains-containing protein 2; NALP2; NALP2NACHT, LRR and PYD containing protein 2; NBS1; NBS1PYRIN-containing APAF1-like protein 2; NLR family, pyrin domain containing 2; NLRP2; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 2; PAN1; PAN1Nucleotide-binding site protein 1; PYPAF2; PYPAF2PYRIN domain and NACHT domain-containing protein 1

Molecular Weight

Mass (kDA):
120.515 kDA

Genomic Context


Human

Location:	19q13.42
Sequence:	19; NC_000019.10 (54965284..55001142)

Tissue Specificity

Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain.

Subcellular Localizations

Cytoplasm.

Diseases

Inflammation
Inflammatory Response
Hydatidiform Mole
Periodontitis
Melanoma
Periodontitis, Juvenile
Periodontal Diseases
Tissue Adhesions
Gingivitis
Infertility
Exanthema

Chronic Periodontitis
Neoplasms
Innate Immune Response
Chromosome Breakage
Bacterial Infections
Arthritis, Juvenile Rheumatoid

Interacting Proteins

PYDC2

Pathways

Secretion
Inflammatory Response
Pathogenesis
Rna Interference
Oogenesis
Response To Lipopolysaccharide
Receptor-mediated Endocytosis
Cell Adhesion
Immune Response
Donor Selection
Metaphase
Endocytosis
Virulence

Embryo Development
Dna Replication
Cell Cycle
S Phase
Innate Immune Response
Bone Remodeling
Meiosis I

PTMs

Phosphorylation

Cleavage

Research Areas

Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NLRP2

References

PMID: 11270363 by Bertin J., et al. The PYRIN domain: a novel motif found in apoptosis and inflammation proteins.

PMID: 11250163 by Martinon F., et al. The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation.