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- Table of Contents
Facts about Neuroligin-2.
Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins.
Human | |
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Gene Name: | NLGN2 |
Uniprot: | Q8NFZ4 |
Entrez: | 57555 |
Belongs to: |
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type-B carboxylesterase/lipase family |
EC 3.1.1; EC 3.1.1.1; KIAA1366neuroligin-2; Neuroligin 2; NLGN2
Mass (kDA):
90.82 kDA
Human | |
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Location: | 17p13.1 |
Sequence: | 17; NC_000017.11 (7405492..7419860) |
Expressed in the blood vessel walls. Detected in colon, brain and pancreas islets of Langerhans (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.
Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane. Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina (By similarity).
PMID: 12669065 by Jamain S., et al. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.
PMID: 9278515 by Irie M., et al. Binding of neuroligins to PSD-95.