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- Table of Contents
Facts about Neuroligin-1.
May promote the initial formation of synapses, but is not vital for this. In vitro, triggers the de novo formation of presynaptic structures.
Human | |
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Gene Name: | NLGN1 |
Uniprot: | Q8N2Q7 |
Entrez: | 22871 |
Belongs to: |
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type-B carboxylesterase/lipase family |
EC 3.1.1; EC 3.1.1.1; KIAA1070neuroligin-1; MGC45115; Neuroligin 1; NL1; Nlg; NLGN1
Mass (kDA):
96.368 kDA
Human | |
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Location: | 3q26.31 |
Sequence: | 3; NC_000003.12 (173395929..174294372) |
Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.
Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic density. Cell junction, synapse, synaptic cleft. Cell junction, synapse, synaptic cell membrane. Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1.
PMID: 20034102 by Rissone A., et al. Characterization of the neuroligin gene family expression and evolution in zebrafish.
PMID: 9278515 by Irie M., et al. Binding of neuroligins to PSD-95.