Phosphatidylinositide phosphatase SAC2 (INPP5F)

Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate into phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 4 and 5 position of inositol, thus playing an essential role in the endocytic recycling (PubMed:25869669).

Regulator of TF:TFRC and integrins recycling pathway, can also be involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895).