Homeobox protein Nkx-6.1 Antibodies

AND NKX6-1 ELISA kits, Homeobox protein Nkx-6.1 Proteins

Many biological assays use antibodies to detect Homeobox protein Nkx-6.1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Homeobox protein Nkx-6.1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Homeobox protein Nkx-6.1 antibodies...

We validate the specificity of these antibodies to Homeobox protein Nkx-6.1 by testing them on tissues known to express NKX6-1 positively and negatively. Browse below to find the NKX6-1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NKX6-1 Infographic by Boster Bio

All NKX6-1 Products

Product

Figures

Specificity

Applications

Price

Anti-Nkx-6.1 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A05760
100ul

nkx6.1 (NKX6-1) (NM_006168) Human Over-expression Lysate

Human

$628
Cat # LS004825
100 µg

NKX6-1 Overview

Facts about Homeobox protein Nkx-6.1.

NKX6-1 3D structure. Source: alphafold

Homeobox protein Nkx-6.1 (NKX6-1)

Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a variety of genes. Involved in the maturation of insulin-producing beta cells in the islets of Langerhans in the secondary transition (By similarity).

Together with NKX2-2 and IRX3 acts to limit the generation of motor neurons into the suitable area of the neural tube. Belongs to the class II proteins of neuronal progenitor variables, which are triggered by SHH signals (By similarity).

Gene Information

Human
Gene Name:	NKX6-1
Uniprot:	P78426
Entrez:	4825

Family

Belongs to:

No superfamily

Alternative Names

Homeobox protein NK-6 homolog A; NK homeo box, family 6, member A; NK homeobox (Drosophila), family 6, A; NK homeobox, family 6, A; NK6 homeobox 1; NK6 transcription factor homolog A; NK6 transcription factor related, locus 1 (Drosophila); NK6 transcription factor related, locus 1; NKX6.1; NKX6-1; NKX6A; NKX6Ahomeobox protein Nkx-6.1

Molecular Weight

Mass (kDA):
37.849 kDA

Genomic Context


Human

Location:	4q21.23
Sequence:	4; NC_000004.12 (84493283..84498234, complement)

Tissue Specificity

Pancreatic beta cells.

Subcellular Localizations

Nucleus.

Diseases

Diabetes Mellitus
Nervousness
Hyperglycemia
Diabetes Mellitus, Non-insulin-dependent
Parkinson Disease
Carcinoma
Fibrosarcoma
Neoplasms
Impaired Glucose Tolerance
Diabetes Mellitus, Insulin-dependent
Insulinoma
Hyperplasia
Meningeal Disorder

Malignant Tumor Of Cervix
Malignant Neoplasms
Cervical Intraepithelial Neoplasia
Diabetes Mellitus, Experimental
Insulin Resistance
Malignant Squamous Cell Neoplasm
Metaplasia

Pathways

Cell Differentiation
Secretion
Pancreas Development
Insulin Secretion
Localization
Methylation
Neurogenesis
Glucose Homeostasis
Cell Cycle
Transdifferentiation
Cell Development
Dna Methylation
Cell Maturation

Spinal Cord Development
Cell Proliferation
Neuron Development
Regeneration
Transport
Cell Activation
Gene Silencing

PTMs

Methylation
Phosphorylation

Cleavage
Acetylation

Dephosphorylation

Research Areas

Pancreatic Stem Cell Markers
Stem Cell Signaling Pathway
Transcription Factors and Regulators

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NKX6-1

References

PMID: 9119408 by Inoue H., et al. Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene.