Nipped-B-like protein Antibodies

AND NIPBL ELISA kits, Nipped-B-like protein Proteins

Many biological assays use antibodies to detect Nipped-B-like protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nipped-B-like protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nipped-B-like protein antibodies...

We validate the specificity of these antibodies to Nipped-B-like protein by testing them on tissues known to express NIPBL positively and negatively. Browse below to find the NIPBL antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NIPBL Infographic by Boster Bio

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Anti-Nipped-B-like protein NIPBL Antibody

Human, Mouse

IHC

$380
Cat # A01939
100ul

NIPBL Overview

Facts about Nipped-B-like protein.

Nipped-B-like protein (NIPBL)

Plays an essential part in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604).

Plays a role in cohesin loading at sites of DNA damage. Its recruitement to double-strand breaks (DSBs) sites happens in a CBX3-, RNF8- and - RNF168-dependent manner whereas its recruitement to UV irradiation-induced DNA damage sites happens in a ATM-, ATR-, RNF8- and RNF168-dependent way (PubMed:28167679).

Gene Information

Human
Gene Name:	NIPBL
Uniprot:	Q6KC79
Entrez:	25836

Family

Belongs to:

SCC2/Nipped-B family

Alternative Names

CDLS1; delangin; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; FLJ44854; IDN3-B; IDN3CDLS; Nipped-B homolog (Drosophila); nipped-B-like protein; SCC2 homolog; Scc2; sister chromatid cohesion 2 homolog

Molecular Weight

Mass (kDA):
316.051 kDA

Genomic Context


Human

Location:	5p13.2
Sequence:	5; NC_000005.10 (36876769..37066413)

Tissue Specificity

Widely expressed. Highly expressed in heart, skeletal muscle, fetal and adult liver, fetal and adult kidney. Expressed at intermediates level in thymus, placenta, peripheral leukocyte and small intestine. Weakly or not expressed in brain, colon, spleen and lung.

Subcellular Localizations

Nucleus. Chromosome.

Diseases

Cornelia De Lange Syndrome
Congenital Abnormality
Growth Retardation
Developmental Disabilities
Developmental Delay (disorder)
Congenital Anomaly Of Face
Limb Defect
Embryonic Mosaic
Multisystem Disorder
Microcephaly
Hereditary Diseases

Impaired Cognition
Craniofacial Abnormalities
Congenital Heart Defects
Autistic Disorder
Malignant Neoplasms

Interacting Proteins

MAU2

Pathways

Sister Chromatid Cohesion
Chromosome Segregation
Meiosis
Mitosis
Dna Repair
Regulation Of Gene Expression
Cell Cycle
Metaphase
Pathogenesis
Anaphase
Translation
Rna Interference
Gene Silencing

Bone Maturation
Aging
Rumination
Histone Modification
Reflex
Reverse Transcription
Dna Damage Checkpoint

PTMs

Acetylation
Methylation

Deacetylation
Cleavage

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NIPBL

References

PMID: 15146185 by Tonkin E.T., et al. NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome.

PMID: 15146186 by Krantz I.D., et al. Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B.