NFE2 Antibodies

AND NFE2 ELISA kits, NFE2 Proteins

Many biological assays use antibodies to detect NFE2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NFE2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NFE2 antibodies...

We validate the specificity of these antibodies to NFE2 by testing them on tissues known to express NFE2 positively and negatively. Browse below to find the NFE2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NFE2 Infographic by Boster Bio

All NFE2 Products

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Product

Figures

Specificity

Applications

Price

Anti-NFE2 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A03765
100ul

Nuclear Factor Erythroid Derived 2 (NFE2) (NM_006163) Human Over-expression Lysate

Human

$628
Cat # LS004778
100 µg

Anti-NFE2 Antibody Picoband®

Human

ELISA, WB

$370
Cat # A03765-1
100 µg/vial

Anti-NFE2 Rabbit Monoclonal Antibody

Human

IP, IF, IHC, ICC, WB

$370
Cat # M03765
100 µl/vial

NFE2 Overview

Facts about Transcription factor NF-E2 45 kDa subunit.

NFE2 3D structure. Source: alphafold

Transcription factor NF-E2 45 kDa subunit (NFE2)

Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR).

This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of both erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif.

Gene Information

Human
Gene Name:	NFE2
Uniprot:	Q16621
Entrez:	4778

Family

Belongs to:

bZIP family

Alternative Names

Leucine zipper protein NF-E2; NF-E2; nuclear factor (erythroid-derived 2), 45kD; nuclear factor (erythroid-derived 2), 45kDa; Nuclear factor, erythroid-derived 2 45 kDa subunit; p45 NF-E2; p45; transcription factor NF-E2 45 kDa subunit

Molecular Weight

Mass (kDA):
41.473 kDA

Genomic Context


Human

Location:	12q13.13
Sequence:	12; NC_000012.12 (54292107..54301037, complement)

Tissue Specificity

Expressed in hematopoietic cells and also in colon and testis.

Subcellular Localizations

Nucleus, PML body. Cytoplasm. The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH.

Diseases

Acute Erythroblastic Leukemia
Leukemia
Anemia
Neoplasms
Hemorrhage
Malignant Neoplasms
Thrombocytosis
Polycythemia
Polycythemia Vera
Anemia, Sickle Cell
Tissue Adhesions
Acute Megakaryocytic Leukemias
Beta Thalassemia

Inflammation
Myeloproliferative Disease
Thrombocythemia, Essential
Hereditary Spherocytosis
Acute Promyelocytic Leukemia
Microcytic Anemia
Pathologic Neovascularization

Interacting Proteins

BTRC
NFE2L3

Pathways

Localization
Cell Differentiation
Megakaryocyte Differentiation
Platelet Formation
Hypersensitivity
Cell Cycle
Megakaryocyte Development
Methylation
Histone Acetylation
Pathogenesis
Hemostasis
Cell Death
Cell Growth

Histone Modification
Cell Maturation
Cell Proliferation
Protein Acetylation
Chromatin Remodeling
Nucleosome Positioning
Transport

PTMs

Acetylation
Methylation
Phosphorylation

Sumoylation
Reduction
Cleavage

Prenylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NFE2

References

PMID: 8248255 by Chan J.Y., et al. Isolation of cDNA encoding the human NF-E2 protein.

PMID: 8355703 by Ney P.A., et al. Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner.