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NFAT5 Antibodies
AND NFAT5 ELISA kits, NFAT5 Proteins
Many biological assays use antibodies to detect NFAT5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NFAT5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NFAT5 antibodies...
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NFAT5 Overview
Facts about Nuclear factor of activated T-cells 5.
Nuclear factor of activated T-cells 5 (NFAT5)
Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity (PubMed:10051678).
Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the existence of DDX5/DDX17 (PubMed:22266867). Binds the DNA consensus sequence 5'- [ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394).
Gene Information
| Human | |
|---|---|
| Gene Name: | NFAT5 |
| Uniprot: | O94916 |
| Entrez: | 10725 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
EC 3.6.1; EC 3.6.3.14; KIAA0827glutamine rich protein H65; NF-AT5NFAT-like protein 1; NFATL1; NFATZ; nuclear factor of activated T-cells 5, tonicity-responsive; OREBP; osmotic response element-binding protein; T-cell transcription factor NFAT5; TonE-binding protein; TonEBP; TONEBPnuclear factor of activated T-cells 5; Tonicity-responsive enhancer-binding protein
Molecular Weight
Mass (kDA):
165.763 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q22.1 |
| Sequence: | 16; NC_000016.10 (69565952..69704654) |
Tissue Specificity
Widely expressed, with highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes.
Subcellular Localizations
Nucleus. Cytoplasm. Nuclear distribution increases under hypertonic conditions.
Diseases
- Disease Of Adrenal Medulla
- Malignant Neoplasms
- Physiological Stress
- Dehydration
- Neoplasms
- Carcinoma
- Cell Invasion
- Hypoxia
- Neoplasm Metastasis
- Deprivation Of Water
- Mammary Neoplasms
- Diabetes Mellitus
Interacting Proteins
- DDX17
- DDX5
- PTPN6
Pathways
- Localization
- Cell Death
- Transport
- Response To Osmotic Stress
- Cell Proliferation
- Rna Interference
- Cell Migration
- Nuclear Export
- Cell Cycle
- Nuclear Import
- Cell Growth
- Cell Motility
- Immune Response
PTMs
- Phosphorylation
- Acetylation
- Dephosphorylation
Research Areas
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NFAT5
bosterbio.com/bosterbio-gene-info-cards/NFAT5
References
PMID: 10051678 by Miyakawa H., et al. Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity.
PMID: 10377394 by Lopez-Rodriguez C., et al. NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun.