Merlin Antibodies

AND NF2 ELISA kits, Merlin Proteins

Many biological assays use antibodies to detect Merlin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Merlin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Merlin antibodies...

We validate the specificity of these antibodies to Merlin by testing them on tissues known to express NF2 positively and negatively. Browse below to find the NF2 antibody that suites your experiment. We have 10 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NF2 Infographic by Boster Bio

All NF2 Products

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Specificity

Applications

Price

Anti-Phospho-Merlin (Ser518) NF2 Antibody

Human, Mouse, Rat

IF, WB

$360
Cat # P00279-1
100 µl

Anti-NF2 / Merlin Monoclonal Antibody

5 Q&As

Human, Mouse, Rat

IP, WB

$370
Cat # M00279
100 μl

Merlin Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$480
Cat # EKC1363
1 kit, containing one 96-well plate and all necessary reagents

Merlin (Phospho-Ser518) Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$540
Cat # EKC2460
1 kit, containing two 96-well plates and all necessary reagents

Anti-NF2/Merlin Antibody Picoband®

2 Q&As

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A00279-2
100 μg/vial

Anti-NF2/Merlin (phospho-S518) Antibody

Human, Mouse, Rat

IF, WB

$482
Cat # A00279S518
100ul

Anti-NF2/Merlin Antibody

Human, Mouse, Rat

IP, IF, ICC, WB

$405
Cat # A00279
100ul

Anti-Phospho-NF2 (S518) Antibody

Human, Mouse, Rat

ELISA, IF, IHC, WB

$380
Cat # A00279S518-1
100ul

Anti-Phospho-NF2 (S10) Antibody

Human, Mouse, Rat

ELISA, IHC-P, WB

$380
Cat # A00279S10
100ul

NF2 (NM_000268) Human Over-expression Lysate

Human

$628
Cat # LS004771
100 µg

NF2 Overview

Facts about Merlin.

NF2 3D structure. Source: alphafold

Merlin (NF2)

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway.

May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating action.

Gene Information

Human
Gene Name:	NF2
Uniprot:	P35240
Entrez:	4771

Family

Belongs to:

No superfamily

Alternative Names

ACN; BANF; Merlin; moesin-ezrin-radixin like; Moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromin 2 (bilateral acoustic neuroma); neurofibromin 2 (merlin); neurofibromin-2; NF2; SCH; Schwannomerlin; Schwannomin

Molecular Weight

Mass (kDA):
69.69 kDA

Genomic Context


Human

Location:	22q12.2
Sequence:	22; NC_000022.11 (29603556..29698600)

Tissue Specificity

Widely expressed. Isoform 1 and isoform 3 are predominant. Isoform 4, isoform 5 and isoform 6 are expressed moderately. Isoform 8 is found at low frequency. Isoform 7, isoform 9 and isoform 10 are not expressed in adult tissues, with the exception of adult retina expressing isoform 10. Isoform 9 is faintly expressed in fetal brain, heart, lung, skeletal muscle and spleen. Fetal thymus expresses isoforms 1, 7, 9 and 10 at similar levels.

Subcellular Localizations

[Isoform 1]: Cell projection, filopodium membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. In a fibroblastic cell line, isoform 1 is found homogeneously distributed over the entire cell, with a particularly strong staining in ruffling membranes and filopodia. Colocalizes with MPP1 in non-myelin-forming Schwann cells. Binds with DCAF1 in the nucleus. The intramolecular association of the FERM domain with the C-terminal tail promotes nuclear accumulation. The unphosphorylated form accumulates predomi