NEURL1 Antibodies

AND NEURL1 ELISA kits, NEURL1 Proteins

Many biological assays use antibodies to detect NEURL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NEURL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NEURL1 antibodies...

We validate the specificity of these antibodies to NEURL1 by testing them on tissues known to express NEURL1 positively and negatively. Browse below to find the NEURL1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NEURL1 Infographic by Boster Bio

All NEURL1 Products

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Product

Figures

Specificity

Applications

Price

Anti-NEURL1 Antibody

1 Q&As

Human, Mouse, Rat

ELISA, IHC-P, WB, IF (paraffin)

$335
Cat # A30740
100ul

Anti-Neuralized-1 (V250) NEURL1 Antibody

Human, Mouse, Rat

IHC

$405
Cat # A11177
100ul

NEURL (NEURL1) (NM_004210) Human Over-expression Lysate

Human

$628
Cat # LS009148
100 µg

NEURL1 Overview

Facts about E3 ubiquitin-protein ligase NEURL1.

NEURL1 3D structure. Source: alphafold

E3 ubiquitin-protein ligase NEURL1 (NEURL1)

Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the creation of spines and functional synaptic contacts by regulating the translational activity of the cytoplasmic polyadenylation element- binding protein CPEB3.

Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can be the E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway.

Gene Information

Human
Gene Name:	NEURL1
Uniprot:	O76050
Entrez:	9148

Family

Belongs to:

No superfamily

Alternative Names

E3 ubiquitin-protein ligase NEURL1

Molecular Weight

Mass (kDA):
61.86 kDA

Genomic Context


Human

Location:	10q24.33
Sequence:	10; NC_000010.11 (103493705..103592546)

Tissue Specificity

Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma (MB) compared with normal cerebellar tissues.

Subcellular Localizations

Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, dendrite. Cell junction, synapse, postsynaptic density. Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface.

PTMs

Lipoprotein

Myristate

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NEURL1

References

PMID: 9519875 by Nakamura H., et al. Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region.

PMID: 11585928 by Vollrath B., et al. Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland.