Sialidase-4 Antibodies

AND NEU4 ELISA kits, Sialidase-4 Proteins

Many biological assays use antibodies to detect Sialidase-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sialidase-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sialidase-4 antibodies...

We validate the specificity of these antibodies to Sialidase-4 by testing them on tissues known to express NEU4 positively and negatively. Browse below to find the NEU4 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NEU4 Infographic by Boster Bio

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NEU4 (NM_080741) Human Over-expression Lysate

Human

$628
Cat # LS129807
100 µg

NEU4 Overview

Facts about Sialidase-4.

NEU4 3D structure. Source: alphafold

Sialidase-4 (NEU4)

May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N- acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc).

Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids. .

Gene Information

Human
Gene Name:	NEU4
Uniprot:	Q8WWR8
Entrez:	129807

Family

Belongs to:

glycosyl hydrolase 33 family

Alternative Names

EC 3.2.1.18; FLJ35928; MGC102757; MGC18222; N-acetyl-alpha-neuraminidase 4; neuraminidase 4; sialidase 4; sialidase-4

Molecular Weight

Mass (kDA):
51.572 kDA

Genomic Context


Human

Location:	2q37.3
Sequence:	2; NC_000002.12 (241809193..241817413)

Tissue Specificity

Ubiquitous with higher expression in heart, skeletal muscle, liver and placenta.

Subcellular Localizations

[Isoform 1]: Membrane; Peripheral membrane protein.; [Isoform 2]: Lysosome lumen. According to PubMed:15213228, isoform 2 is soluble, N-glycosylated and found in the lumen of lysosomes. However, no signal sequence nor N-glycosylation site is predicted from the sequence.

Diseases

Malignant Neoplasms
Influenza
Neoplasms
Malignant Paraganglionic Neoplasm
Hepatitis
Murine Hepatitis
Tissue Adhesions
Cholera
Colonic Neoplasms
Carcinogenesis
Type I Mucolipidosis
Malignant Tumor Of Colon
Headache

Adenocarcinoma
Mucolipidoses
Nervousness
Pertussis
Neuraminidase 1 Deficiency
Infective Disorder
Neuroblastoma

Interacting Proteins

AP2B1
MDFI
PLSCR1
TCF4
TRIP6

Pathways

Localization
Cell Adhesion
Cell Migration
Cytokine Production
Cell Differentiation
Monocyte Differentiation
Pathogenesis
Cell Proliferation
Brain Development
Glycosylation
Immune Response
Tropism
Conjugation

Methylation
Endothelial Cell Migration
Phagocytosis
Cell Cycle
Cell Motility
S Phase
Cell Growth

PTMs

Acetylation
Phosphorylation
Carboxylation

Cleavage
Glycosylation
Amination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NEU4

References

PMID: 14962670 by Monti E., et al. Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family.

PMID: 15213228 by Seyrantepe V., et al. Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells.