This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
NEK6 Antibodies
AND NEK6 ELISA kits, NEK6 Proteins
Many biological assays use antibodies to detect NEK6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NEK6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NEK6 antibodies...
Previous: CCN4
Next: WDR4
NEK6 Infographic by Boster Bio
All NEK6 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M03740
100 µl
Cat # M03740
100 µl
NEK6 Overview
Facts about Serine/threonine-protein kinase Nek6.
Serine/threonine-protein kinase Nek6 (NEK6)
Protein kinase that plays an important role in mitotic cell cycle progression (PubMed:14563848). Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis (PubMed:19414596).
Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 (PubMed:12054534, PubMed:20873783). Phosphorylates KIF11 to promote mitotic spindle formation (PubMed:19001501).
Gene Information
| Human | |
|---|---|
| Gene Name: | NEK6 |
| Uniprot: | Q9HC98 |
| Entrez: | 10783 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11.1; Never in mitosis A-related kinase 6; NIMA (never in mitosis gene a)-related kinase 6; NimA-related protein kinase 6; Protein kinase SID6-1512; putative serine-threonine protein kinase; serine/threonine-protein kinase Nek6; SID6-1512
Molecular Weight
Mass (kDA):
35.714 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q33.3 |
| Sequence: | 9; NC_000009.12 (124257606..124353307) |
Tissue Specificity
Ubiquitous, with highest expression in heart and skeletal muscle.
Subcellular Localizations
Cytoplasm. Nucleus. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Colocalizes with APBB1 at the nuclear speckles. Colocalizes with PIN1 in the nucleus. Colocalizes with ATF4, CIR1, ARHGAP33, ANKRA2, CDC42, NEK9, RAD26L, RBBP6, RPS7, TRIP4, RELB and PHF1 in the centrosome. Localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis.
Diseases
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Neoplasms
- Carcinoma
- Aneuploidy
- Malignant Neoplasm Of Lung
- Malignant Neoplasm Of Urinary Bladder
- Carcinogenesis
- Liver Carcinoma
- Malignant Paraganglionic Neoplasm
- Metaplastic Cell Transformation
- Liver Neoplasms
- Carcinoma, Transitional Cell
Interacting Proteins
- AES
- CCDC36
- HSD17B14
- IKZF1
- IKZF3
- INCA1
- KRT31
- KRT40
- LNX1
- LZTS2
Pathways
- Mitosis
- Cell Cycle
- Spindle Assembly
- Cytokinesis
- Senescence
- Cell Cycle Arrest
- Cell Division
- Oncogenesis
- Metaphase
- Spindle Organization
- Cellular Senescence
- M Phase
- Anaphase
PTMs
- Phosphorylation
Research Areas
- GPCR
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NEK6
bosterbio.com/bosterbio-gene-info-cards/NEK6
References
PMID: 12054534 by Hashimoto Y., et al. Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase.
PMID: 12840024 by Belham C., et al. A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.