NEDD8 Antibodies

NEDD8

Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M.

Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and consequently promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. .

Gene Information

Human
Gene Name:	NEDD8
Uniprot:	Q15843
Entrez:	4738

Family

Belongs to:
ubiquitin family

Alternative Names

FLJ43224; MGC104393; MGC125896; MGC125897; NEDD8; NEDD-8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; neural precursor cell expressed, developmentally down-regulated 8; Rub1; Ubiquitin-like protein Nedd8

Molecular Weight

Mass (kDA):
9.072 kDA

Genomic Context

Human
Location:	14q12
Sequence:	14; NC_000014.9 (24216857..24232367, complement)

Tissue Specificity

Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.

Subcellular Localizations

Nucleus. Mainly nuclear.

Diseases

• Neoplasms
• Malignant Neoplasms
• Cell Transformation, Neoplastic
• Carcinoma
• Von Hippel-lindau Syndrome
• Alzheimer's Disease
• Neurodegenerative Disorders
• Parkinson Disease
• Growth Arrest
• Leukemia
• Kidney Neoplasm
• Hyperplasia

• Renal Cell Carcinoma
• Acute Promyelocytic Leukemia
• Down Syndrome
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Cancer Patients And Suicide And Depression
• Liver Neoplasms

Interacting Proteins

• BTRC
• CUL1
• KHNYN
• POLI
• RAD23A

• RPL11
• RPL7
• RPS20
• RPS3
• RPS7

• STON2
• UBE2M
• UBXN7

Pathways

• Conjugation
• Cell Cycle
• Localization
• Proteolysis
• Cell Growth
• Cell Death
• Cell Proliferation
• Pathogenesis
• S Phase
• Dna Replication
• Dna Repair
• Cell Cycle Arrest
• Mitosis

• Protein Neddylation
• Translation
• Autophagy
• Protein Ubiquitination
• Rna Interference
• Cullin Deneddylation
• Cell Division

PTMs

• Ubiquitination
• Cleavage
• Phosphorylation
• Sumoylation
• Acetylation

• Deamidation
• Methylation
• Reduction
• Hydroxylation
• Dephosphorylation

Research Areas

• Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NEDD8

Steven and Ana Boster Bio: Best Uses Of The NEDD8 Marker

This article focuses on Steven and Ana Boster Bio: Best Uses Of The NeDD8 Marker. You'll be taught about Boster Biological Technology, TSINGKE and Gene Infographics. You'll also learn how to make the most of NEDD8. If you'd like to know more about the NEDD8 gene, continue reading!

Ana Boster Bio: Best Uses Of The NEDD8 Marker

The NEDD8 marker is a protein that associates with a particular subunit of DNA, is referred to as NEDD8. Boster antibodies exhibit high affinity and are frequently cited in the scientific community. In addition to this, they have been validated by ELISA, Western Blotting, and immunohistochemistry. Ana Boster Bio: The Best Uses for the NEDD8 Marker.

Dr. Ana Boster completed her Ph.D. at the University of Oregon in 2018. Prior to joining the Brody lab she was an undergraduate at Georgia State University. To pursue her graduate studies, she transferred to OHSU. Her thesis focuses on the role that HuR. HuR protein in pancreatic metastasis. Code Bio, which makes a targeted nanocarrier that silences HuR and is her partner. In addition to her research, she enjoys playing tennis, hiking, and playing pranks on her colleagues in the lab.

Steven Boster Bio: Gene Infographics

The Steven Boster Bio: Gene infographics use the NEDD8 gene as the basis of their studies. They provide basic details about each gene within the human and mouse genomes. The search bar for genes lets users to find the gene they are interested in. This tool is available to researchers around the world. For more information, go to Steven Boster's website. It's accessible at geneinfographics.org.

TSINGKE Biotechnology

Celemics has signed a contract to supply its reagents, software and equipment to Chinese biotech company TSINGKE Biological Technology. Both companies will jointly pioneer various applications of NGS and will concentrate on marketing their brands and creating an undisputed position in the fast-growing Chinese NGS market. The company's mission as stated by the company, is to assist Chinese scientists in solving a variety of biological issues. The company is among the fastest-growing companies in China and has been supplying genomic sequences to the global research community for more than ten years.

Boster

In the field of molecular biology antibodies against the NEDD8 marker are of prime importance. Boster's antibodies have been extensively utilized in research and have been extensively referenced over the last 25 years. The high affinity and specificity of the Boster antibodies are recognized by the research community and have been validated on Western Blotting, Immunohistochemistry, and ELISA.

The Boster Bio NEDD8 Marker antibody is an anti-Human Glycophorin A or CD235a protein that reacts with human cell lines. It is not hazardous and is made in a solution of 10mM PBS containing 0.05 percent BSA or azide. It can also be used with a blocking peptide of various lengths. FDA-approved, the safety of the antibody was tested by immunofluorescence, WB and an ELISA.

The NEDD8 pathway is crucial to normal cell function as per molecular biology. In addition to regulating cell growth and proliferation, CRLs that are regulated by NEDD8 ubiquitinate many proteins like the transcription factor Skp2. These inhibitors are crucial for normal cellular function, and cancer usually occurs when NEDD8 is in a state of disregulation. This inhibition of NEDD8 is an effective treatment strategy.